Hori Amane, Kume Daisuke, Saito Ryuji, Hasegawa Daisuke, Suijo Kenichi, Mizuno Masaki, Hotta Norio
College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Japan Society for the Promotion of Science, Tokyo, Japan.
Am J Physiol Regul Integr Comp Physiol. 2025 Mar 1;328(3):R242-R252. doi: 10.1152/ajpregu.00258.2024. Epub 2025 Jan 20.
Persistent stressful situations can have detrimental cardiovascular effects; however, effects on the blood pressure (BP) response to exercise have not been fully examined. This study investigated the impact of a 2-wk stressful situation on the exercise pressor response. Eight healthy male university paramedic trainees underwent a 2-wk paramedic hospital training and a control period study. Pre- and postintervention, BP responses to the exercise test [2-min submaximal isometric handgrip (IHG) exercise followed by postexercise muscle ischemia (PEMI)] and cold pressure test (CPT) were assessed. A stress biomarker, salivary α-amylase (sAA) activity, significantly increased after hospital training (Pre: 8.8 ± 4.6; Post: 15.5 ± 7.3 kU/L; = 0.036), whereas no significant changes were observed in the control period (Pre: 11.3 ± 3.6; Post: 10.4 ± 4.5 kU/L). Although no significant trial (hospital training vs. control)-by-intervention (pre- vs. post-2-wk period) interactions were detected in the mean arterial pressure (MAP) response to PEMI or CPT, a significant interaction in the MAP response to IHG exercise was noted (Δ48.9 ± 11.2 to Δ55.5 ± 9.1 mmHg, hospital training; Δ53.2 ± 14.1 to Δ51.2 ± 11.9 mmHg, control; = 0.035). Consequently, changes in the sAA and MAP preintervention to postintervention showed a significant correlation (τ = 0.397, = 0.036). Results showed that stressful paramedic hospital training augmented BP response to IHG exercise. This suggests that prolonged stressful situations increase pressor response to exercise, particularly in cases involving healthy young men. Exposure to prolonged stressful situations augmented the blood pressure response to submaximal isometric exercise in healthy young men. This finding suggests that monitoring cardiovascular responses during exercise under chronic stress conditions could be important.
持续的压力状况可能会对心血管产生有害影响；然而，其对运动时血压（BP）反应的影响尚未得到充分研究。本研究调查了为期2周的压力状况对运动升压反应的影响。八名健康的男性大学护理专业实习生接受了为期2周的护理医院培训和一个对照期研究。在干预前后，评估了对运动测试[2分钟次最大等长握力（IHG）运动，随后进行运动后肌肉缺血（PEMI）]和冷压测试（CPT）的血压反应。一种压力生物标志物，唾液α淀粉酶（sAA）活性，在医院培训后显著增加（干预前：8.8±4.6；干预后：15.5±7.3 kU/L；P = 0.036），而在对照期未观察到显著变化（干预前：11.3±3.6；干预后：10.4±4.5 kU/L）。尽管在对PEMI或CPT的平均动脉压（MAP）反应中未检测到显著的试验（医院培训与对照）×干预（2周前与2周后）交互作用，但在对IHG运动的MAP反应中观察到显著交互作用（Δ48.9±11.2至Δ55.5±9.1 mmHg，医院培训；Δ53.2±14.1至Δ51.2±11.9 mmHg，对照；P = 0.035）。因此，干预前至干预后sAA和MAP的变化显示出显著相关性（τ = 0.397，P = 0.036）。结果表明，紧张的护理医院培训增强了对IHG运动的血压反应。这表明长期的压力状况会增加对运动的升压反应，尤其是在涉及健康年轻男性的情况下。长期暴露于压力状况会增强健康年轻男性对次最大等长运动的血压反应。这一发现表明，在慢性压力条件下运动期间监测心血管反应可能很重要。
