Bach Mathias Jacobsen, Larsen Mia E, Kellberg Amanda O, Henriksen Alexander C, Fuglsang Stefan, Rasmussen Inge Lise, Lonsdale Markus Nowak, Lubberink Mark, Marner Lisbeth
Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
J Cereb Blood Flow Metab. 2025 Jan 20:271678X251313743. doi: 10.1177/0271678X251313743.
Obtaining the arterial input function (AIF) is essential for quantitative regional cerebral perfusion (rCBF) measurements using [O]HO PET. However, arterial blood sampling is invasive and complicates the scanning procedure. We propose a new non-invasive dual scan technique with an image derived input function (IDIF) from an additional heart scan. Six patients and two healthy subjects underwent [O]HO PET imaging of 1) heart and brain during baseline, and 2) heart and brain after infusion of acetazolamide. The IDIF was extracted from the left ventricle of the heart and compared to the AIF. The rCBF was compared for six bilateral cortical regions. AIFs and IDIFs showed strong agreement. rCBF with AIF and IDIF showed strong correlation for both baseline rCBF (R = 0.99, slope = 0.89 CI: [0.87; 0.91], p < 0.0001) and acetazolamide rCBF (R = 0.98, slope = 0.93, CI:[0.90;0.97], p < 0.0001) but showed a positive bias of 0.047 mL/(g·min) [-0.025; +0.119] for baseline and 0.024 [-1.04, +1.53] mL/(g·min) for acetazolamide. In conclusion, the invasive arterial cannulation can be replaced by an additional scan of the heart with a minor bias of rCBF estimation. The method is applicable to all scanner systems.
获取动脉输入函数（AIF）对于使用[O]HO PET进行定量局部脑血流灌注（rCBF）测量至关重要。然而，动脉血采样具有侵入性，会使扫描过程复杂化。我们提出了一种新的非侵入性双重扫描技术，通过额外的心脏扫描获得图像衍生输入函数（IDIF）。六名患者和两名健康受试者接受了[O]HO PET成像，1）在基线时进行心脏和脑部成像，2）在注射乙酰唑胺后进行心脏和脑部成像。从心脏左心室提取IDIF并与AIF进行比较。对六个双侧皮质区域的rCBF进行了比较。AIF和IDIF显示出高度一致性。使用AIF和IDIF测得的rCBF在基线rCBF（R = 0.99，斜率 = 0.89，置信区间：[0.87; 0.91]，p < 0.0001）和乙酰唑胺rCBF（R = 0.98，斜率 = 0.93，置信区间：[0.90; 0.97]，p < 0.0001）方面均显示出高度相关性，但在基线时显示出0.047 mL/（g·min）[-0.025; +0.119]的正偏差，在乙酰唑胺情况下显示出0.024 [-1.04, +1.53] mL/（g·min）的正偏差。总之，侵入性动脉插管可以通过额外的心脏扫描来替代，rCBF估计的偏差较小。该方法适用于所有扫描系统。
