Bailly C, Roinel N, Amiel C
Pflugers Arch. 1985 Jan;403(1):28-34. doi: 10.1007/BF00583277.
The effects of glucagon and PTH on electrolyte reabsorption in the distal tubule were investigated in rats deprived of vasopressin, calcitonin, PTH, and glucagon. Micropunctures of distal tubule, at a late and an early site of a same nephron, have been performed in 23 rats, nine control, seven infused with glucagon (5 ng X min-1 X 100 g-1 b.w.) and seven with PTH (5 mU X min-1 X 100 g-1 b.w.). The Ca and Mg reabsorptive capacity of the distal segment was increased by glucagon and by PTH. Moreover, fractional Na and Cl reabsorption was significantly higher than in control during PTH administration. A K secretion appeared during the administration of both hormones. No phosphate net transport was observed in any group. Finally, the data presented here, together with those previously reported, indicate that the increase of Ca and Mg renal reabsorption observed with glucagon and PTH results from an effect located in both Henle's loop, where the bulk of Ca and Mg is reabsorbed, and the distal tubule.
在去除了血管加压素、降钙素、甲状旁腺激素（PTH）和胰高血糖素的大鼠中，研究了胰高血糖素和PTH对远端小管电解质重吸收的影响。在23只大鼠身上对同一个肾单位的远端小管晚期和早期部位进行了微穿刺，其中9只为对照，7只输注胰高血糖素（5 ng·min⁻¹·100 g⁻¹体重），7只输注PTH（5 mU·min⁻¹·100 g⁻¹体重）。胰高血糖素和PTH均可增加远端小管段对钙和镁的重吸收能力。此外，在输注PTH期间，钠和氯的分数重吸收显著高于对照组。在两种激素给药期间均出现钾分泌。在任何组中均未观察到磷酸盐的净转运。最后，此处呈现的数据与先前报道的数据一起表明，胰高血糖素和PTH所观察到的肾脏对钙和镁重吸收的增加是由于位于亨氏袢（大部分钙和镁在此处重吸收）和远端小管的作用所致。
