Elalouf J M, Roinel N, de Rouffignac C
Pflugers Arch. 1984 Jun;401(2):167-73. doi: 10.1007/BF00583877.
The effects of (1-desamino-8-D-arginine) vasopressin (dDAVP) on water and electrolyte transport in the distal tubule were investigated by micropuncture. Since, in addition to antidiuretic hormone, parathyroid hormone, calcitonin and glucagon stimulate the adenylate-cyclase system in this nephron segment, experiments were performed on hormone-deprived rats, i.e. homozygous DI Brattleboro rats with reduced levels of endogenous parathyroid hormone, calcitonin and glucagon. Along the distal tubule, dDAVP enhanced water, Cl, Na and Ca reabsorption and sharply increased net K secretion. Phosphate transport was left unchanged and Mg reabsorption was not significantly altered by dDAVP between the early and late distal tubule. Antidiuretic hormone also slightly increased water filtration rate in the superficial nephron, which rose in proportion to whole kidney glomerular filtration rate. It is concluded that, in rats: antidiuretic hormone stimulates water, NaCl and Ca absorption and enhances K secretion along the distal tubule and the tubular effects of dDAVP on electrolyte transport in the loop and distal tubule are responsible for decreasing Mg and Ca urinary excretion.
通过微穿刺研究了（1-去氨基-8-D-精氨酸）血管加压素（dDAVP）对远曲小管水和电解质转运的影响。由于除抗利尿激素外，甲状旁腺激素、降钙素和胰高血糖素也能刺激该肾单位段的腺苷酸环化酶系统，因此实验在激素缺乏的大鼠身上进行，即内源性甲状旁腺激素、降钙素和胰高血糖素水平降低的纯合子DI Brattleboro大鼠。沿远曲小管，dDAVP增强了水、Cl、Na和Ca的重吸收，并显著增加了净K分泌。磷酸盐转运未发生变化，dDAVP在远曲小管早期和晚期之间对Mg重吸收没有显著改变。抗利尿激素也略微增加了浅表肾单位的水滤过率，其与全肾肾小球滤过率成比例上升。得出结论：在大鼠中，抗利尿激素刺激水、NaCl和Ca的吸收，并增强远曲小管的K分泌，dDAVP对髓袢和远曲小管电解质转运的肾小管作用导致Mg和Ca尿排泄减少。
