Kokane Gauri, Kharkar Viraj, Kalsi Harjit, Wagh Ashvin, Kolte Deepak, Kumar Barun, Patil Tejal
MDS Oral and Maxillofacial Surgery, Consultant Oral and Maxillofacial Surgeon, Navi Mumbai, Maharashtra, India.
Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, Maharashtra, India.
Natl J Maxillofac Surg. 2024 Sep-Dec;15(3):360-366. doi: 10.4103/njms.njms_132_23. Epub 2024 Nov 16.
Early diagnosis of oral potentially malignant disorders (OPMDs) can bring about considerable improvement in reducing the statistics related to morbidity and mortality associated with oral cancer. The objective of this review was to summarize advanced diagnostic aids used for OPMDs. Pubmed, Embase, and Cochrane Central Register of Controlled Trials electronic databases from 1969 to 2022 focus on advanced diagnostic techniques for potentially malignant disorders. An electronic database was searched for keywords: "Potentially malignant disorders", "Early diagnostic aids", advanced diagnostic aids in oral PMDs, precancerous lesions, precancerous conditions, diagnosis of potentially malignant disorders, and artificial intelligence in oral cancer. A total of 42 studies met inclusion and exclusion criteria. The mean standard deviation (σ) was calculated as 3.129 and specificity and sensitivity were obtained at a confidence interval (CI) of 95%. The pooled value for sensitivity and specificity of each modality of diagnostic aid was calculated. In conclusion, advanced diagnostic techniques would be very useful in the early detection of OPMDs. It is important for dentists and dental practitioners to be well versed in all available techniques of diagnosis. Implementation of early diagnostic aids at a larger screening platform could be beneficial in overcoming the cost factor involved and may improve the probability burden of oral cancer-related mortality.
口腔潜在恶性疾病（OPMDs）的早期诊断能够在降低与口腔癌相关的发病率和死亡率统计数据方面带来显著改善。本综述的目的是总结用于OPMDs的先进诊断辅助手段。对1969年至2022年的Pubmed、Embase和Cochrane对照试验中央注册库电子数据库进行检索，重点关注潜在恶性疾病的先进诊断技术。在电子数据库中搜索关键词：“潜在恶性疾病”、“早期诊断辅助手段”、口腔潜在恶性疾病的先进诊断辅助手段、癌前病变、癌前状况、潜在恶性疾病的诊断以及口腔癌中的人工智能。共有42项研究符合纳入和排除标准。计算出平均标准差（σ）为3.129，并在95%的置信区间（CI）下获得特异性和敏感性。计算了每种诊断辅助手段的敏感性和特异性的合并值。总之，先进的诊断技术在OPMDs的早期检测中非常有用。牙科医生和牙科从业者精通所有可用的诊断技术很重要。在更大的筛查平台上实施早期诊断辅助手段可能有助于克服所涉及的成本因素，并可能改善口腔癌相关死亡率的概率负担。
