Gu Joyce H, Smothermon Nicholas, Kohli Jusnimrat, Samarneh Mark
Medicine, Lake Erie College of Osteopathic Medicine, Greensburg, USA.
Internal Medicine, St. John's Riverside Hospital, Yonkers, USA.
Cureus. 2024 Dec 18;16(12):e75973. doi: 10.7759/cureus.75973. eCollection 2024 Dec.
We report an interesting case of an elderly male patient with splenic marginal zone lymphoma with a monoclonal cluster of differentiation (CD)5+ B cells. The patient developed signs of renal injury and was evaluated via serum protein electrophoresis and immunofixation electrophoresis, which revealed monoclonal gammopathy with elevated free lambda light chain. However, a bone biopsy ruled out a diagnosis of multiple myeloma. Upon renal biopsy, the patient was diagnosed with lambda light chain cast nephropathy. However, the patient's condition further deteriorated, and the patient eventually expired. This case highlights light chain cast nephropathy as a rare yet serious complication of lymphomas and, in particular, splenic marginal zone lymphoma.
我们报告了一例有趣的老年男性患者，患有伴有单克隆分化簇（CD）5+ B细胞的脾边缘区淋巴瘤。该患者出现肾损伤迹象，并通过血清蛋白电泳和免疫固定电泳进行评估，结果显示单克隆丙种球蛋白病伴游离λ轻链升高。然而，骨活检排除了多发性骨髓瘤的诊断。经肾活检，该患者被诊断为λ轻链管型肾病。然而，患者病情进一步恶化，最终死亡。该病例凸显了轻链管型肾病是淋巴瘤尤其是脾边缘区淋巴瘤一种罕见但严重的并发症。
