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一名患有食管鳞状细胞癌的免疫功能低下患者发生多杀巴斯德菌菌血症:病例报告

Pasteurella multocida Bacteremia in an Immunocompromised Patient With Esophageal Squamous Cell Carcinoma: A Case Report.

作者信息

Lopes Freitas Rafaela, Reis Fábio, Ruiz Pena Eduarda

机构信息

Internal Medicine Service, Pedro Hispano Hospital - Matosinhos Local Health Unit, Matosinhos, Porto, PRT.

Infectious Diseases Service, Pedro Hispano Hospital - Matosinhos Local Health Unit, Matosinhos, Porto, PRT.

出版信息

Cureus. 2024 Dec 18;16(12):e75924. doi: 10.7759/cureus.75924. eCollection 2024 Dec.

DOI:10.7759/cureus.75924
PMID:39830547
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11740001/
Abstract

is a facultative anaerobic Gram-negative coccobacillus that represents a rare cause of systemic infection in immunocompromised patients. This report presents the case of a 59-year-old man with advanced squamous cell carcinoma of the oesophagus, recently undergoing radiotherapy and chemotherapy, halted due to cytopenias, including neutropenia. The patient, who owned a cat but denied any recent bites or scratches, developed bacteremia caused by with presumed pulmonary and renal foci. Early diagnosis and prompt treatment with intravenous cephalosporins led to clinical improvement. This case highlights the need to consider zoonotic pathogens in vulnerable patients and the importance of early therapeutic intervention. A brief review of current literature on is included, underscoring diagnostic challenges and treatment approaches for this rare entity.

摘要

是一种兼性厌氧革兰氏阴性球杆菌,是免疫功能低下患者发生全身感染的罕见原因。本报告介绍了一名59岁男性病例,该患者患有晚期食管鳞状细胞癌,近期正在接受放疗和化疗,但因血细胞减少症(包括中性粒细胞减少症)而中断治疗。该患者养了一只猫,但否认近期有任何咬伤或抓伤,发生了由 引起的菌血症,推测有肺部和肾脏病灶。早期诊断并及时静脉注射头孢菌素治疗后临床症状改善。该病例强调了在脆弱患者中考虑人畜共患病原体的必要性以及早期治疗干预的重要性。本文还简要回顾了关于 的当前文献,强调了这一罕见病原体的诊断挑战和治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac8/11740001/5cfde94b1f40/cureus-0016-00000075924-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac8/11740001/85a058f9a9ba/cureus-0016-00000075924-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac8/11740001/b9a82c2648c4/cureus-0016-00000075924-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac8/11740001/5cfde94b1f40/cureus-0016-00000075924-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac8/11740001/85a058f9a9ba/cureus-0016-00000075924-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac8/11740001/b9a82c2648c4/cureus-0016-00000075924-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac8/11740001/5cfde94b1f40/cureus-0016-00000075924-i03.jpg

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Clinical features of pasteurellosis without an animal bite or scratch in comparison with bite/scratch pasteurellosis.无动物咬伤或抓伤的巴氏杆菌病的临床特征与咬伤/抓伤巴氏杆菌病的比较。
J Infect Chemother. 2024 Aug;30(8):820-823. doi: 10.1016/j.jiac.2024.02.002. Epub 2024 Feb 17.
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Pet-related bacterial zoonotic infections: Three cases of severe infections in the immunocompromised host.
与宠物相关的细菌性人畜共患病感染:免疫功能低下宿主中的三例严重感染病例。
IDCases. 2022 Sep 26;30:e01623. doi: 10.1016/j.idcr.2022.e01623. eCollection 2022.
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J Community Hosp Intern Med Perspect. 2022 Apr 12;12(2):50-52. doi: 10.55729/2000-9666.1039. eCollection 2022.
5
Zoonotic Bacterial Respiratory Infections Associated With Cats and Dogs: A Case Series and Literature Review.与猫和狗相关的人畜共患细菌性呼吸道感染:病例系列及文献综述
Cureus. 2022 Apr 23;14(4):e24414. doi: 10.7759/cureus.24414. eCollection 2022 Apr.
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Int J Infect Dis. 2022 Mar;116:197-203. doi: 10.1016/j.ijid.2022.01.028. Epub 2022 Jan 19.
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