Emerg Infect Dis. 2024 Oct;30(10):1987-1997. doi: 10.3201/eid3010.240245.
Pasteurella spp. can cause fatal zoonotic infections in humans. We performed a multicenter study to investigate the prevalence and clinical features of Pasteurella infections in South Korea during 2018‒2022. We also conducted a collaborative systematic review and meta-analysis of the global burden of Pasteurella bacteremia. The study included 283 cases found an increasing trend in Pasteurella infections. Blood cultures were positive in 8/35 (22.9%) cases sampled, for overall bacteremia-associated rate of 2.8% (8/283). Aging was a significant risk factor for bacteremia (odds ratio 1.05 [95% CI 1.01-1.10]), according to multivariate analyses. For the meta-analysis, we included a total of 2,012 cases from 10 studies. The pooled prevalence of bacteremia was 12.4% (95% CI 7.3%-18.6%) and of mortality 8.4% (95% CI 2.7%-16.5%). Our findings reflect the need for greater understanding of the increase in Pasteurella infections and the global burden of Pasteurella bacteremia to determine appropriate case management.
巴斯德氏菌属可引起人类致命的人畜共患病感染。我们进行了一项多中心研究，以调查 2018-2022 年期间韩国巴斯德氏菌感染的流行率和临床特征。我们还对巴斯德氏菌菌血症的全球负担进行了合作系统评价和荟萃分析。该研究包括 283 例病例，发现巴斯德氏菌感染呈上升趋势。对 35 例样本进行血培养，阳性 8 例（22.9%），总菌血症相关率为 2.8%（8/283）。多变量分析显示，年龄是菌血症的显著危险因素（优势比 1.05 [95%置信区间 1.01-1.10]）。对于荟萃分析，我们共纳入了来自 10 项研究的 2012 例病例。菌血症的总患病率为 12.4%（95%置信区间 7.3%-18.6%），死亡率为 8.4%（95%置信区间 2.7%-16.5%）。我们的研究结果反映了需要更深入地了解巴斯德氏菌感染的增加和巴斯德氏菌菌血症的全球负担，以确定适当的病例管理。
