Baranov V G, Gasparian E G, Konradi L I, Sitnikova A M
Probl Endokrinol (Mosk). 1985 Jan-Feb;31(1):3-6.
A study of the frequency of "remissions" of disorders of the glucose tolerance test (GTT) of the diabetic type depending on therapy: diet and diet combined with sulfanilurea derivatives in 130 patients revealed the absence of significant dependence on the method of treatment of patients with a low level of glycemia following glucose load (below 11 and 8.25 mmol/l after 1 and 2 hours, respectively) and a significant rise of the frequency of the GTT return to normal (from 7% to 40%) with the use of sulfanilurea derivatives together with diabetic management from the moment of diagnosing the disease in patients with a higher level of glycemia in the process of the GTT (over 11 and 8.25 mmol/l 1 and 2 h, respectively after glucose load). On the other hand, in 38% of persons with the different GTT disturbances of the diabetic type receiving no therapy, with glycemia level after 1 hour up to 11 mmol/l and 8.25 mmol/l after 2 h, spontaneous GTT improvement can be observed in 3-6 years to come. To raise the frequency of remissions, the authors recommend differentiated treatment of patients with GTT of the diabetic type in the initial period of treatment depending on the glycemia level in the process of the GTT.
一项针对130例糖尿病型葡萄糖耐量试验（GTT）紊乱“缓解”频率的研究，该研究根据治疗方法进行：饮食以及饮食联合磺胺脲类衍生物。研究发现，葡萄糖负荷后血糖水平较低（1小时和2小时后分别低于11 mmol/l和8.25 mmol/l）的患者，其缓解频率与治疗方法无显著相关性；而对于葡萄糖耐量试验过程中血糖水平较高（葡萄糖负荷后1小时和2小时分别超过11 mmol/l和8.25 mmol/l）的患者，从疾病诊断时起，使用磺胺脲类衍生物并结合糖尿病管理，GTT恢复正常的频率显著提高（从7%升至40%）。另一方面，在38%未接受治疗、糖尿病型GTT存在不同紊乱且1小时后血糖水平达11 mmol/l、2小时后达8.25 mmol/l的患者中，未来3至6年内可观察到GTT自发改善。为提高缓解频率，作者建议在治疗初期根据糖尿病型GTT患者在GTT过程中的血糖水平进行差异化治疗。
