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[人乳中蛋白质合成调节激素的研究]

[Study of protein synthesis regulating hormones in human milk].

作者信息

Adugamov L F, Chernikov M P

出版信息

Probl Endokrinol (Mosk). 1985 Jan-Feb;31(1):31-3.

PMID:3983098
Abstract

A study was made of the content in human milk of hormones which regulate together with their specific function processes of protein assimilation and synthesis. These hormones (thyroxine, triiodothyronine, 17 beta-estradiol, prolactin, 11-hydroxycorticosteroids) were determined in the first days of lactation, in the most important period in the nutrition of a newborn and in the formation of lactation. Chromatography, radioimmunoassay and fluorometry were used. The aim of the study was to determine the levels of exogenous hormones which influence the metabolism of proteins received by a newborn. During the first 10 days of lactation the content of prolactin in human milk was 154.5-546.0 muunits/ml, that of 17 beta-estradiol 34.2-124.4 pg/ml, that of thyroxine 0.5-1.1 micrograms%, that of triiodothyronine 8.6-20.8 ng%. A possible involvement of milk hormones in the regulation of anabolic processes of a newborn as well as changes in the first 3-6 days of lactation of the prolactin and 17 beta-estradiol content in milk in connection with the regulation of the start of lactation are discussed.

摘要

对人乳中与蛋白质同化和合成的特定功能过程共同起调节作用的激素含量进行了一项研究。在哺乳期的最初几天,即在新生儿营养的最重要时期以及泌乳形成期,对这些激素(甲状腺素、三碘甲状腺原氨酸、17β-雌二醇、催乳素、11-羟基皮质类固醇)进行了测定。采用了色谱法、放射免疫分析法和荧光测定法。该研究的目的是确定影响新生儿所摄入蛋白质代谢的外源激素水平。在哺乳期的前10天,人乳中催乳素的含量为154.5 - 546.0微单位/毫升,17β-雌二醇为34.2 - 124.4皮克/毫升,甲状腺素为0.5 - 1.1微克%,三碘甲状腺原氨酸为8.6 - 20.8纳克%。讨论了乳中激素可能参与新生儿合成代谢过程的调节,以及泌乳开始后的第3 - 6天乳中催乳素和17β-雌二醇含量的变化与泌乳调节的关系。

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