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[脑啡肽对内分泌腺钙调节功能的影响]

[Effect of enkephalins on the calcium-regulating function of the endocrine glands].

作者信息

Zoloev G K, Slepushkin V D, Akhmetshina A G, Kenikh N I

出版信息

Probl Endokrinol (Mosk). 1985 Jan-Feb;31(1):42-4.

PMID:3983100
Abstract

Experiments on rats have shown that administration of a synthetic analog of leuenkephalin at a dose of 100 mg/kg did not change the content of the immunoreactive parathyroid hormone in the blood plasma but removed the parathyroidin stimulating effect on the cAMP concentration in the renal tissue and AP activity in the blood. It is concluded that enkephalins do not influence the secretion and metabolism of the parathyroid hormone but block its peripheral effects and stimulate thyroid C-cell function.

摘要

对大鼠的实验表明,以100毫克/千克的剂量给予亮氨酸脑啡肽的合成类似物,不会改变血浆中免疫反应性甲状旁腺激素的含量,但会消除甲状旁腺素对肾组织中环磷酸腺苷(cAMP)浓度和血液中碱性磷酸酶(AP)活性的刺激作用。得出的结论是,脑啡肽不影响甲状旁腺激素的分泌和代谢,但会阻断其外周效应并刺激甲状腺C细胞功能。

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