Zhao Kuan, Yu Ze, Wang Youyang, Feng Wei
Department of Psychological Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032, People's Republic of China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China.
Nat Sci Sleep. 2025 Jan 13;17:69-79. doi: 10.2147/NSS.S492373. eCollection 2025.
The incidence of insomnia in cancer patients is significantly higher than in the general population. Chronic insomnia imposes pronounced physical and psychological burdens on cancer patients, affecting their quality of life and survival rate. This study aims to investigate insomnia in cancer patients and further analyze potentially related factors.
Oncology outpatients treated at Fudan University Shanghai Cancer Center were consecutively recruited. Demographic information and clinical features, such as type of cancer and treatment status, were collected. Insomnia was assessed using the Insomnia Severity Index (ISI).
A total of 146 patients participated in the study, with the majority suffering from breast tumors (40.4%), gastrointestinal tract tumors (18.5%), and endocrine tumors (5.8%). Among these patients, 25 (17.1%) did not report insomnia, 69 (47.3%) had subclinical insomnia, and 52 (35.6%) reached the level of clinical insomnia. Older patients aged 41-50 years (Estimate = -3.49, 95% CI, -6.99 to 0.00, p = 0.05) and those with higher education levels (Estimate = -2.72, 95% CI, -4.88 to -0.55, p = 0.01) were less likely to have higher ISI total scores. In contrast, undergoing chemotherapy (Estimate = 3.86, 95% CI, 0.53 to 7.19, p = 0.02) was associated with higher ISI total scores. Gender, age, education, treatment modalities correlated with ISI subitem scores.
The prevalence of insomnia is higher in oncology patients and is associated with gender, age, education, tumor type, and treatment modality. Screening and interventions for insomnia should be emphasized in the whole-course management of oncology patients.
癌症患者失眠的发生率显著高于普通人群。慢性失眠给癌症患者带来了明显的身心负担，影响他们的生活质量和生存率。本研究旨在调查癌症患者的失眠情况，并进一步分析潜在的相关因素。
连续招募在复旦大学附属肿瘤医院接受治疗的肿瘤门诊患者。收集人口统计学信息和临床特征，如癌症类型和治疗状态。使用失眠严重程度指数（ISI）评估失眠情况。
共有146名患者参与研究，其中大多数患有乳腺肿瘤（40.4%）、胃肠道肿瘤（18.5%）和内分泌肿瘤（5.8%）。在这些患者中，25名（17.1%）未报告失眠，69名（47.3%）有亚临床失眠，52名（35.6%）达到临床失眠水平。41 - 50岁的老年患者（估计值 = -3.49，95%置信区间，-6.99至0.00，p = 0.05）和教育程度较高的患者（估计值 = -2.72，95%置信区间，-4.88至-0.55，p = 0.01）ISI总分较高的可能性较小。相比之下，接受化疗（估计值 = 3.86，95%置信区间，0.53至7.19，p = 0.02）与ISI总分较高相关。性别、年龄、教育程度、治疗方式与ISI子项评分相关。
肿瘤患者失眠的患病率较高，且与性别、年龄、教育程度、肿瘤类型和治疗方式有关。在肿瘤患者的全程管理中应强调对失眠的筛查和干预。
