Department of Stomatology, Bethune International Peace Hospital, Shijiazhuang, Hebei, PR China.
Department of Respiratory and Critical Care, Bethune International Peace Hospital, Shijiazhuang, Hebei, PR China.
Postgrad Med. 2024 Sep;136(7):749-756. doi: 10.1080/00325481.2024.2399500. Epub 2024 Sep 5.
This cross-sectional study aimed to evaluate sleep quality and perceived stress levels in Chinese patients with active minor recurrent aphthous stomatitis (MiRAS) lesions, as well as to investigate the potential relationship between sleep quality and perceived stress levels and the risk of MiRAS episodes.
The study population consisted of individuals recruited from a Chinese cohort who underwent medical and oral examinations from March 2022 to August 2023. All participants completed a set of uniform anonymous questionnaires, which included sociodemographic characteristics, clinical information, the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI) and the Perceived Stress Scale (PSS-14). Statistical analysis was conducted using the independent sample t test, Mann-Whitney U test, Pearson's chi-square test and Pearson's correlation analysis. After adjusting for potential confounders (age, gender, marital status, and education level), multivariate logistic regression analyses were performed to assess the associations of sleep quality and perceived stress levels with the risk of MiRAS episodes. Additionally, restricted cubic spline curves were constructed to visualize these correlations.
A total of 329 eligible volunteers participated in the study, comprising 122 Chinese MiRAS patients and 207 healthy controls without MiRAS. Compared to healthy participants, MiRAS patients exhibited significantly higher PSQI and ISI scores ( = 0.000). However, no statistically significant difference was observed between the two groups regarding PSS-14 scores or its two subscales ( > 0.05). Multiple regression analysis indicated that lower sleep quality was significantly associated with an increased risk of MiRAS episodes ( = 0.000), whereas no statistically significant relationship was found between perceived stress levels and the risk of MiRAS episodes ( > 0.05).
Maintaining a regular bedtime and improving sleep quality may contribute to reducing the incidence and recurrence of MiRAS, while psychological intervention may be ineffective for MiRAS patients.
本横断面研究旨在评估患有活动性复发性阿弗他口炎（MiRAS）病变的中国患者的睡眠质量和感知压力水平，并探讨睡眠质量和感知压力水平与 MiRAS 发作风险之间的潜在关系。
研究人群由 2022 年 3 月至 2023 年 8 月期间接受医学和口腔检查的中国队列中招募的个体组成。所有参与者完成了一套统一的匿名问卷，其中包括社会人口统计学特征、临床信息、匹兹堡睡眠质量指数（PSQI）、失眠严重程度指数（ISI）和感知压力量表（PSS-14）。采用独立样本 t 检验、Mann-Whitney U 检验、Pearson 卡方检验和 Pearson 相关分析进行统计学分析。在调整潜在混杂因素（年龄、性别、婚姻状况和教育水平）后，进行多变量 logistic 回归分析，以评估睡眠质量和感知压力水平与 MiRAS 发作风险的关联。此外，构建了限制立方样条曲线来可视化这些关联。
共有 329 名符合条件的志愿者参与了研究，包括 122 名中国 MiRAS 患者和 207 名无 MiRAS 的健康对照者。与健康参与者相比，MiRAS 患者的 PSQI 和 ISI 评分显著更高（ = 0.000）。然而，两组之间的 PSS-14 评分或其两个子量表评分没有统计学差异（ > 0.05）。多回归分析表明，较低的睡眠质量与 MiRAS 发作风险增加显著相关（ = 0.000），而感知压力水平与 MiRAS 发作风险之间没有统计学关联（ > 0.05）。
保持规律的就寝时间和改善睡眠质量可能有助于降低 MiRAS 的发病率和复发率，而心理干预可能对 MiRAS 患者无效。
