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利用早产儿身体成分评估指导新生儿营养。

Utilizing preterm infant body composition assessments to guide neonatal nutrition.

作者信息

Buck Catherine O

机构信息

Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.

出版信息

Curr Opin Pediatr. 2025 Apr 1;37(2):191-197. doi: 10.1097/MOP.0000000000001434. Epub 2025 Jan 2.

Abstract

PURPOSE OF REVIEW

The use of body composition to assess the quality of infant growth may add valuable information to pediatric clinical care. Preterm infants have differences in their fat and muscle mass development compared with infants born at term, which may be related to their early nutritional exposures. This review focuses on recent studies examining early nutrition in preterm infants and related body composition outcomes in the newborn period and beyond.

RECENT FINDINGS

Overall, the evidence shows that early nutrient delivery in parenteral nutrition and through formula supplementation or human milk fortification is associated with increased fat-free mass or lean mass in early life. However, future research is needed to fully understand the link between these body composition changes and longitudinal outcomes in preterm infants.

SUMMARY

Inclusion of body composition assessments in preterm infant nutrition research is critical to understand the factors associated with differences in adiposity and lean mass development in preterm infants. Medical fragility in preterm infants limits the routine use of body composition assessment tools which are currently validated, and additional studies are needed to thoroughly assess other methods which may be more feasible to integrate into bedside routine.

摘要

综述目的

利用身体成分评估婴儿生长质量可为儿科临床护理增添有价值的信息。与足月儿相比,早产儿的脂肪和肌肉量发育存在差异,这可能与其早期营养暴露有关。本综述重点关注近期关于早产儿早期营养及新生儿期及以后相关身体成分结果的研究。

最新发现

总体而言,证据表明肠外营养以及通过配方奶补充或母乳强化进行的早期营养供给与生命早期无脂肪量或瘦体重增加有关。然而,需要进一步研究以充分理解这些身体成分变化与早产儿纵向结局之间的联系。

总结

将身体成分评估纳入早产儿营养研究对于理解与早产儿肥胖和瘦体重发育差异相关的因素至关重要。早产儿的医学脆弱性限制了目前已验证的身体成分评估工具的常规使用,需要更多研究来全面评估其他可能更易于整合到床边常规操作中的方法。

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本文引用的文献

2
Growth at 2 years corrected age in preterm infants discharged on two different breast milk enhancements: An observational study.
J Pediatr Gastroenterol Nutr. 2024 Nov;79(5):1047-1055. doi: 10.1002/jpn3.12341. Epub 2024 Aug 21.
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