Shao Shuming, Zhang Yimin, Liu Jie, Zeng Chaomei, Qin Jiong, Liu Zheng, Zhang Xiaorui
Department of Pediatrics, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China.
Department of Maternal and Child Health, School of Public Health, Peking University, No.38, Xueyuan Road, Beijing, 100191, China.
Eur Child Adolesc Psychiatry. 2025 Jan 20. doi: 10.1007/s00787-025-02639-3.
This study aims to explore the long-term physical, neurological, social and emotional development outcomes of the offspring born to patients with systemic lupus erythematosus (SLE), and to provide insights that can assist pediatricians in enhancing the long-term prognosis of these children. We conducted a cross-sectional study on the offspring of SLE patients who had undergone pregnancy and were admitted to our obstetrics department between January 1, 2016 and September 30, 2021. The control group consisted of offspring born to mothers without connective tissue disease, and was matched 1:1 based on age (birth date ± 1 month) with the offspring of SLE patients. Physical development, including measurements of weight and height (length), was assessed. The Ages and Stages Questionnaires, Third Edition (ASQ-3) was utilized to evaluate development in five domains: communication, gross motor, fine motor, problem solving, and personal-social. The Ages and Stages Questionnaires: Social-Emotional (ASQ: SE) was used to assess social-emotional development. Weight, height (length), BMI (body mass index), and ASQ-3 domain scores at different ages and for both genders were standardized into Z-scores for comparison. In the SLE group, the offspring demonstrated higher BMI Z-scores, higher rates of obesity, and increased probabilities of abnormal social-emotional development screening. In addition, their problem solving domain Z-scores were lower as compared to the control group. All of these differences were statistically significant. It is recommended that SLE patients should pay close attention to sensible feeding practices after the birth of their offspring to prevent the occurrence of obesity. Furthermore, there should be an emphasis on strengthening monitoring and intervention efforts to enhance the problem solving abilities and social-emotional development of the offspring. By implementing these measures, the overall long-term developmental outcomes of children born to SLE patients can be improved.
本研究旨在探讨系统性红斑狼疮（SLE）患者所生孩子的长期身体、神经、社会和情感发育结局，并提供有助于儿科医生改善这些儿童长期预后的见解。我们对2016年1月1日至2021年9月30日期间在我院产科住院分娩的SLE患者的后代进行了一项横断面研究。对照组由无结缔组织病母亲所生的后代组成，并根据年龄（出生日期±1个月）与SLE患者的后代进行1:1匹配。评估了身体发育情况，包括体重和身高（身长）测量。使用《年龄与发育进程问卷》第三版（ASQ-3）评估五个领域的发育情况：沟通、大运动、精细运动、问题解决和个人社交。使用《年龄与发育进程问卷：社会情感》（ASQ: SE）评估社会情感发育。将不同年龄和性别的体重、身高（身长）、BMI（体重指数）和ASQ-3领域得分标准化为Z分数进行比较。在SLE组中，后代的BMI Z分数较高，肥胖率较高，社会情感发育筛查异常的概率增加。此外，与对照组相比，他们在问题解决领域的Z分数较低。所有这些差异均具有统计学意义。建议SLE患者在产后密切关注合理喂养方式，以预防肥胖的发生。此外，应强调加强监测和干预力度，以提高后代的问题解决能力和社会情感发育。通过实施这些措施，可以改善SLE患者所生孩子的总体长期发育结局。
