Facchinetti Fabio, Gambineri Alessandra, Aimaretti Gianluca, Ferlin Alberto, Laganà Antonio Simone, Moghetti Paolo, Montanino Oliva Mario, Unfer Vittorio, Colao Annamaria
The Experts Group on Inositol in Basic and Clinical Research (EGOI), Rome, Italy.
University of Modena and Reggio Emilia, Modena, Italy.
J Endocrinol Invest. 2025 Jan 20. doi: 10.1007/s40618-025-02533-4.
To gather the current opinion among Italian gynecologists and endocrinologists regarding the definition, diagnosis, and treatment of polycystic ovary syndrome (PCOS).
A Delphi survey consisting of 26 statements was designed by a nine-member panel (consisting of members from the Italian Society of Endocrinology (SIE) and the Experts Group AQon Inositol in Basic and Clinical Research and on PCOS (EGOI-PCOS)) and distributed to 102 experts in PCOS across the fields of gynecology and endocrinology. Consensus was defined as an agreement between at least 70% of responders. Participants completed three rounds of statements, ranking their level of agreement.
Of the initial 26 statements, 25 reached an adequate consensus, with an overall response rate of 73%. The statements were divided into three sections: definition and current understanding, diagnosis, and treatment. Of the statements that reached consensus, near total agreement was reached in the first two sections, whereas there was a divergence of opinion in terms of optimum treatment strategy between the gynecology and endocrinology subgroups.
It was agreed that the current clinical guidelines are inadequate for clinical and scientific practice, with most responders advocating for the inclusion of metabolic factors. Furthermore, the consensus opinion advocated for the diversification of hyperandrogenic vs. non-hyperandrogenic phenotypes. This survey gives a snapshot of the current understanding of PCOS in the Italian healthcare community.
收集意大利妇科医生和内分泌学家关于多囊卵巢综合征（PCOS）的定义、诊断和治疗的当前观点。
由一个由九名成员组成的小组（包括来自意大利内分泌学会（SIE）以及基础和临床研究及PCOS领域的肌醇AQon专家小组（EGOI-PCOS）的成员）设计了一项包含26条陈述的德尔菲调查，并分发给102名妇科和内分泌领域的PCOS专家。共识被定义为至少70%的受访者达成一致。参与者完成三轮陈述，对他们的同意程度进行排名。
在最初的26条陈述中，25条达成了充分的共识，总体回复率为73%。这些陈述分为三个部分：定义和当前理解、诊断和治疗。在达成共识的陈述中，前两个部分几乎完全达成一致，而妇科和内分泌亚组在最佳治疗策略方面存在意见分歧。
大家一致认为，当前的临床指南不足以用于临床和科学实践，大多数受访者主张纳入代谢因素。此外，共识意见主张区分高雄激素血症与非高雄激素血症表型。这项调查展示了意大利医疗界对PCOS的当前理解。
