Kim Jae Hoon, Kim Ju-El, Kang Seong-Jun, Yoon Jeong-Kee
Department of Systems Biotechnology, Chung-Ang University, Anseong-Si, Gyeonggi-Do, 17546, Republic of Korea.
Tissue Eng Regen Med. 2025 Jan 20. doi: 10.1007/s13770-024-00695-5.
Exosomes and exosome mimetics are used as alternatives to cell therapy. They have shown potential in treating skin disorders by fortifying the skin barrier, mediating angiogenesis, and regulating the immune response while minimizing side effects. Currently, numerous studies have applied exosome therapy to treat atopic dermatitis (AD) caused by a weakened skin barrier and chronic inflammation. Research on exosomes and exosome mimetics represents a promising avenue for tissue regeneration, potentially paving the way for new therapeutic options. However, the efficacy of the therapy remains poorly understood. Also, the potential of exosome mimetics as alternatives to exosomes in skin therapy remains underexplored.
Here, we reviewed the pathological features and current therapies of AD. Next, we reviewed the application of exosomes and exosome mimetics in regenerative medicine. Finally, we highlighted the therapeutic effects of exosomes based on their cell source and assessed whether exosome mimetics are viable alternatives.
Exosome therapy may treat AD due to its skin regenerative properties, and exosome mimetics may offer an equally effective yet more efficient alternative. Research on exosomes and exosome mimetics represents a promising avenue for tissue regeneration, potentially paving the way for new therapeutic options.
外泌体和外泌体模拟物被用作细胞治疗的替代物。它们在通过强化皮肤屏障、介导血管生成和调节免疫反应同时最小化副作用来治疗皮肤疾病方面已显示出潜力。目前，众多研究已将外泌体疗法应用于治疗由皮肤屏障减弱和慢性炎症引起的特应性皮炎（AD）。对外泌体和外泌体模拟物的研究代表了组织再生的一个有前景的途径，可能为新的治疗选择铺平道路。然而，该疗法的疗效仍知之甚少。此外，外泌体模拟物作为皮肤治疗中外泌体替代物的潜力仍未得到充分探索。
在此，我们回顾了AD的病理特征和当前疗法。接下来，我们回顾了外泌体和外泌体模拟物在再生医学中的应用。最后，我们强调了基于细胞来源的外泌体的治疗效果，并评估外泌体模拟物是否是可行的替代物。
外泌体疗法因其皮肤再生特性可能治疗AD，外泌体模拟物可能提供一种同样有效但更高效的替代物。对外泌体和外泌体模拟物的研究代表了组织再生的一个有前景的途径，可能为新的治疗选择铺平道路。
