Jiang Ting, Wang Xinming, Zheng Lingli, Ren Tao, Li Yan, Li Jing
School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan Province, China.
Department of Pharmacy, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China.
Medicine (Baltimore). 2025 Jan 17;104(3):e41067. doi: 10.1097/MD.0000000000041067.
Chemotherapy is one of the main treatments for breast cancer patients. However, chemotherapy-related nausea and vomiting can significantly reduce patients' quality of life and lead to electrolyte disturbance and metabolic imbalance in severe cases. Therefore, to identify the risk factors for nausea and vomiting during chemotherapy in these patients is very important. This retrospective study included 113 patients with breast cancer undergoing chemotherapy and used antiemetic drugs hospitalized in First Affiliated Hospital of Chengdu Medical College between January 1, 2021, and January 1, 2023. Of these, 26 (23.01%) patients developed nausea and vomiting. The univariate and multivariate logistics regression analyses showed that patients combined with diabetes, hypertension, chronic hepatitis B, >65 years of age, >8 cycles of chemotherapy, and had a history of nausea and vomiting are the risk factors for nausea and vomiting. However, due to the limited sample size and some risk factor data missing from this study, further prospective studies are needed to improve and verify.
化疗是乳腺癌患者的主要治疗方法之一。然而，化疗相关的恶心和呕吐会显著降低患者的生活质量，严重时会导致电解质紊乱和代谢失衡。因此，识别这些患者化疗期间恶心和呕吐的危险因素非常重要。这项回顾性研究纳入了2021年1月1日至2023年1月1日期间在成都医学院第一附属医院住院接受化疗并使用止吐药物的113例乳腺癌患者。其中，26例（23.01%）患者出现恶心和呕吐。单因素和多因素逻辑回归分析显示，合并糖尿病、高血压、慢性乙型肝炎、年龄>65岁、化疗周期>8个周期以及有恶心和呕吐病史的患者是恶心和呕吐的危险因素。然而，由于本研究样本量有限且部分危险因素数据缺失，需要进一步开展前瞻性研究以完善和验证。
