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由1型猪链球菌引起的人类感染性心内膜炎和感染性休克。

Human infective endocarditis and septic shock caused by Streptococcus suis serotype 1.

作者信息

Yang Wei, Yang Chun, Lu Xiaoxiong

机构信息

Wuming Hospital of Guangxi Medical University, Nanning, China.

Department of Natural Resources of Guangxi Zhuang Autonomous Region, Nanning, China.

出版信息

BMC Infect Dis. 2025 Jan 20;25(1):86. doi: 10.1186/s12879-025-10489-2.

DOI:10.1186/s12879-025-10489-2
PMID:39833717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11748241/
Abstract

Streptococcus suis(SS) infection is a zoonotic acute infectious disease, SS infective endocarditis is relatively rare, there is no case report of Streptococcus suis Serotype 1(SS1) causing mitral valve infection.The rapid progression of this patient's infection and the severe damage to the valve structure differ from the previous understanding of the relatively low virulence of SS1. Early diagnosis and selection of the correct antibiotic treatment according to the drug sensitivity is very important. If the infection causes damage to the structure of the body's mitral valve, resulting in regurgitation of blood and heart failure, prompt surgical treatment should be performed to improve heart function.

摘要

猪链球菌(SS)感染是一种人畜共患的急性传染病,猪链球菌感染性心内膜炎相对少见,尚无猪链球菌1型(SS1)引起二尖瓣感染的病例报道。该患者感染进展迅速,瓣膜结构严重受损,这与以往认为SS1毒力相对较低的认识不同。早期诊断并根据药敏选择正确的抗生素治疗非常重要。如果感染导致人体二尖瓣结构受损,引起血液反流和心力衰竭,应及时进行手术治疗以改善心功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0836/11748241/93c43b3dfa92/12879_2025_10489_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0836/11748241/93c43b3dfa92/12879_2025_10489_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0836/11748241/93c43b3dfa92/12879_2025_10489_Fig1_HTML.jpg

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本文引用的文献

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Genomic comparison of two Streptococcus suis serotype 1 strains recovered from porcine and human disease cases.猪源和人源 1 型猪链球菌分离株的基因组比较。
Sci Rep. 2023 Apr 3;13(1):5380. doi: 10.1038/s41598-023-32724-z.
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Comparative Virulence and Genomic Analysis of Isolates.分离株的比较毒力和基因组分析
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Fatal case of bacteremia caused by Streptococcus suis in a splenectomized man and a review of the European literature.
脾切除术后猪链球菌致败血性休克 1 例并文献复习
Acta Microbiol Immunol Hung. 2020 Mar 30;67(3):148-155. doi: 10.1556/030.2020.01123. Print 2020 Oct 21.
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Streptococcus suis-Associated Meningitis, Bali, Indonesia, 2014-2017.2014-2017 年印度尼西亚巴厘岛猪链球菌相关性脑膜炎。
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Combination Therapy Strategies Against Multiple-Resistant .针对多重耐药的联合治疗策略
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