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分离株的比较毒力和基因组分析

Comparative Virulence and Genomic Analysis of Isolates.

作者信息

Nicholson Tracy L, Waack Ursula, Anderson Tavis K, Bayles Darrell O, Zaia Sam R, Goertz Isaiah, Eppinger Mark, Hau Samantha J, Brockmeier Susan L, Shore Sarah M

机构信息

National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, United States.

Oak Ridge Institute for Science and Education, United States Department of Energy, Oak Ridge, TN, United States.

出版信息

Front Microbiol. 2021 Jan 26;11:620843. doi: 10.3389/fmicb.2020.620843. eCollection 2020.

DOI:10.3389/fmicb.2020.620843
PMID:33574803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7870872/
Abstract

is a zoonotic bacterial swine pathogen causing substantial economic and health burdens to the pork industry. Mechanisms used by to colonize and cause disease remain unknown and vaccines and/or intervention strategies currently do not exist. Studies addressing virulence mechanisms used by have been complicated because different isolates can cause a spectrum of disease outcomes ranging from lethal systemic disease to asymptomatic carriage. The objectives of this study were to evaluate the virulence capacity of nine United States isolates following intranasal challenge in swine and then perform comparative genomic analyses to identify genomic attributes associated with swine-virulent phenotypes. No correlation was found between the capacity to cause disease in swine and the functional characteristics of genome size, serotype, sequence type (ST), or virulence-associated phenotypes. A search for orthologs found in highly virulent isolates and not found in non-virulent isolates revealed numerous predicted protein coding sequences specific to each category. While none of these predicted protein coding sequences have been previously characterized as potential virulence factors, this analysis does provide a reliable one-to-one assignment of specific genes of interest that could prove useful in future allelic replacement and/or functional genomic studies. Collectively, this report provides a framework for future allelic replacement and/or functional genomic studies investigating genetic characteristics underlying the spectrum of disease outcomes caused by isolates.

摘要

是一种人畜共患的猪源细菌病原体，给猪肉行业带来了巨大的经济和健康负担。其用于定植和致病的机制尚不清楚，目前也不存在疫苗和/或干预策略。由于不同的分离株可导致从致命的全身性疾病到无症状携带等一系列疾病结果，因此研究其毒力机制变得复杂。本研究的目的是评估九株美国分离株在猪鼻内接种后的毒力，并进行比较基因组分析，以确定与猪毒力表型相关的基因组特征。在猪致病能力与基因组大小、血清型、序列类型（ST）或毒力相关表型的功能特征之间未发现相关性。在高毒力分离株中发现而在无毒力分离株中未发现的直系同源物搜索揭示了每个类别特有的大量预测蛋白质编码序列。虽然这些预测的蛋白质编码序列以前都没有被表征为潜在的毒力因子，但该分析确实为特定感兴趣基因提供了可靠的一对一分配，这可能在未来的等位基因替换和/或功能基因组研究中有用。总体而言，本报告为未来等位基因替换和/或功能基因组研究提供了一个框架，以研究由分离株引起的一系列疾病结果背后的遗传特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/f2d3ee476e94/fmicb-11-620843-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/0dba15943708/fmicb-11-620843-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/6e973ba691a3/fmicb-11-620843-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/9bdae375e778/fmicb-11-620843-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/6d6bf33ee130/fmicb-11-620843-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/f2d3ee476e94/fmicb-11-620843-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/0dba15943708/fmicb-11-620843-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/6e973ba691a3/fmicb-11-620843-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/c5ab78aa73e3/fmicb-11-620843-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/ad3ed91c3a26/fmicb-11-620843-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/9bdae375e778/fmicb-11-620843-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a70d/7870872/6d6bf33ee130/fmicb-11-620843-g006.jpg
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J Clin Microbiol. 2019 Aug 26;57(9). doi: 10.1128/JCM.00377-19. Print 2019 Sep.
3
The bacteriocin from the prophylactic candidate Streptococcus suis 90-1330 is widely distributed across S. suis isolates and appears encoded in an integrative and conjugative element.
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4
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6
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