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CESTsimu：一款用于光谱和空间CEST模拟的开源图形用户界面。

CESTsimu: An open-source GUI for spectral and spatial CEST simulation.

作者信息

Zhang Huabin, Qiu Bensheng, Xu Jiadi, Chan Kannie Wy, Huang Jianpan

机构信息

Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China.

出版信息

Magn Reson Med. 2025 Jun;93(6):2595-2609. doi: 10.1002/mrm.30430. Epub 2025 Jan 20.

DOI:10.1002/mrm.30430
PMID:39834082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11971506/
Abstract

PURPOSE

The aim of this study was to create a user-friendly CEST simulation tool with a GUI for both spectral (1D Z-spectra) and spatial (2D phantom) CEST experiments, making the CEST simulation easier to perform.

METHODS

CESTsimu was developed using MATLAB App Designer. It consists of three modules: Saturation Settings, Exchange Settings, and Phantom Settings. CESTsimu can not only import/export files in the defined format but can also import files generated by other existing simulation platforms (e.g. pulseq-CEST).

RESULTS

The 1D Z-spectrum simulation results demonstrated the effectiveness of CESTsimu in simulating Z-spectra under various saturation ( and ) and exchange settings (concentration and exchange rate). The 2D simulation results showed that CESTsimu can generate an arbitrary number of phantoms with different shapes under different noise conditions. Notably, CESTsimu could also simulate and inhomogeneity in 2D patterns that mimicked practical conditions. Moreover, the accuracy of CESTsimu was validated by simulating 8 cases in the BMsim challenge.

CONCLUSION

We developed a user-friendly CESTsimu GUI for intuitively simulating CEST experiments under diverse saturation and exchange settings in 1D and 2D conditions. CESTsimu has the potential to facilitate the broad utilization of CEST MRI among a wide range of users.

摘要

目的

本研究的目的是创建一个用户友好的CEST模拟工具，该工具带有用于光谱（1D Z谱）和空间（2D体模）CEST实验的图形用户界面（GUI），使CEST模拟更易于执行。

方法

CESTsimu使用MATLAB App Designer开发。它由三个模块组成：饱和设置、交换设置和体模设置。CESTsimu不仅可以导入/导出定义格式的文件，还可以导入由其他现有模拟平台（例如pulseq-CEST）生成的文件。

结果

1D Z谱模拟结果证明了CESTsimu在模拟各种饱和（和）和交换设置（浓度和交换率）下的Z谱方面的有效性。2D模拟结果表明，CESTsimu可以在不同噪声条件下生成任意数量的不同形状的体模。值得注意的是，CESTsimu还可以模拟模仿实际条件的2D模式中的和不均匀性。此外，通过在BMsim挑战中模拟8个案例验证了CESTsimu的准确性。

结论

我们开发了一个用户友好的CESTsimu GUI，用于在1D和2D条件下直观地模拟不同饱和和交换设置下的CEST实验。CESTsimu有潜力促进CEST MRI在广泛用户中的广泛应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/fb5c62520983/MRM-93-2595-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/bed30d74a127/MRM-93-2595-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/1b47df6f4b04/MRM-93-2595-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/ab940bbc2aa1/MRM-93-2595-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/b419f115cbcf/MRM-93-2595-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/02cc88412ca5/MRM-93-2595-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/a1794f3be5ec/MRM-93-2595-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/bd450f584372/MRM-93-2595-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/ec42bb8b7eb0/MRM-93-2595-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/fb5c62520983/MRM-93-2595-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/bed30d74a127/MRM-93-2595-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/1b47df6f4b04/MRM-93-2595-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/ab940bbc2aa1/MRM-93-2595-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/b419f115cbcf/MRM-93-2595-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/02cc88412ca5/MRM-93-2595-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/a1794f3be5ec/MRM-93-2595-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/bd450f584372/MRM-93-2595-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/ec42bb8b7eb0/MRM-93-2595-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9b/11971506/fb5c62520983/MRM-93-2595-g009.jpg

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2
Whole-cerebrum guanidino and amide CEST mapping at 3 T by a 3D stack-of-spirals gradient echo acquisition.3T 全脑胍基和酰胺 CEST 成像的 3D 螺旋叠加梯度回波采集。
Magn Reson Med. 2024 Oct;92(4):1456-1470. doi: 10.1002/mrm.30134. Epub 2024 May 15.
3
Analytical solution of the Bloch-McConnell equations for steady-state CEST Z-spectra.
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Magn Reson Imaging. 2024 Jun;109:74-82. doi: 10.1016/j.mri.2024.02.015. Epub 2024 Feb 29.
4
Adjustment of rotation and saturation effects (AROSE) for CEST imaging.CEST 成像的旋转和饱和效应调整（AROSE）。
Magn Reson Med. 2024 Mar;91(3):1016-1029. doi: 10.1002/mrm.29938. Epub 2023 Nov 27.
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Creatine mapping of the brain at 3T by CEST MRI.通过化学交换饱和转移磁共振成像（CEST MRI）在3T条件下对大脑进行肌酸成像。
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