Bosco Gerardo, Brizzolari Andrea, Paganini Matteo, Camporesi Enrico, Vezzoli Alessandra, Mrakic-Sposta Simona
Department of Biomedical Sciences, University of Padua, Padua.
TEAM Health Anaesthesia, Tampa General Hospital, Tampa, Florida.
Eur J Transl Myol. 2025 Mar 31;35(1). doi: 10.4081/ejtm.2025.12783. Epub 2025 Jan 20.
Hyperbaric Oxygen Therapy (HBOT) is a non-invasive method of O2 delivery that induces systemic hyperoxia. Hyperbaric chamber consists of a pressure vessel and a compressed breathing gas supply, which can regulate internal pressure. The chamber delivers 100% O2 to patients according to predetermined protocols and is monitored by trained personnel. HBOT relies on increasing the inspired O2 fraction (fiO2) and elevating the partial pressure of O2 (pO2). O2 is typically administered at pressures between 1.5 and 3.0 ATA for 60 to 120 minutes, depending on the clinical presentation. Currently, there are 15 indications for HBOT approved by the Undersea and Hyperbaric Medicine Society, categorized into three groups: emergency medicine, wound healing acceleration, and antimicrobial effects. The present narrative review aims to elucidate the mechanisms action underlying HBOT, particularly oxy-inflammation, in various pathologies within these categories.
高压氧疗法（HBOT）是一种无创的氧气输送方法，可诱导全身高氧状态。高压氧舱由一个压力容器和一个压缩呼吸气体供应装置组成，能够调节内部压力。该舱根据预定方案为患者提供100%的氧气，并由经过培训的人员进行监测。HBOT依靠增加吸入氧分数（FiO2）和提高氧分压（pO2）。根据临床表现，氧气通常在1.5至3.0个绝对大气压的压力下给予60至120分钟。目前，水下和高压氧医学协会批准了15种HBOT适应症，分为三组：急诊医学、加速伤口愈合和抗菌作用。本叙述性综述旨在阐明HBOT在这些类别中的各种病理情况下的作用机制，特别是氧炎症。
