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首例肾移植受者体内完全机器人辅助膀胱切除术及新膀胱术

First full intracorporeal robotic cystectomy and neobladder in a renal transplant recipient.

作者信息

Tillou Xavier, Le Bloa Lisa, Courteille Vanja, Bechade Clemence, Waeckel Thibaut

机构信息

UNICAEN, Urology and Transplantation Department, Normandie University, CHU de Caen, Avenue de la Côte de Nacre, Caen 14000, France.

UNICAEN, Anesthesiology and Critical Care Department, Normandie University, CHU de Caen, Avenue de la Côte de Nacre, Caen 14000, France.

出版信息

J Surg Case Rep. 2025 Jan 20;2025(1):rjaf009. doi: 10.1093/jscr/rjaf009. eCollection 2025 Jan.

DOI:10.1093/jscr/rjaf009
PMID:39834474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11745229/
Abstract

The literature regarding robotic-assisted radical cystectomy in kidney transplant recipients is limited. We present the first reported case of robotic-assisted radical cystectomy with a full intracorporeal orthotopic neobladder in a kidney transplant recipient. A 36-year-old man was diagnosed with muscle-invasive urothelial carcinoma 12 years after kidney transplantation. His immunosuppressive regimen consisted of everolimus, mycophenolate mofetil, and prednisolone. After cystectomy and left lymph node dissection, we used a U-shaped neobladder technique slightly modified to adapt to the fixed position of the renal transplant ureter. The surgical time was 305 min, and the blood loss was 200 ml. The patient was discharged 16 days after hospitalization with no surgical complications. Histological analysis revealed no UC (pT0N0) with disseminated carcinoma . Seven months after the surgery, no signs of recurrence or distant/lymph node metastasis were observed. No urinary leakage with complete bladder emptying was reported. Serum creatinine clearance rate was 51 ml/min. Immunosuppressive regimen was not modified after surgery.

摘要

关于肾移植受者机器人辅助根治性膀胱切除术的文献有限。我们报告了首例肾移植受者行机器人辅助根治性膀胱切除术并完全体内原位新膀胱的病例。一名36岁男性在肾移植12年后被诊断为肌层浸润性尿路上皮癌。他的免疫抑制方案包括依维莫司、霉酚酸酯和泼尼松龙。膀胱切除和左侧淋巴结清扫术后,我们采用了一种略作修改的U形新膀胱技术,以适应肾移植输尿管的固定位置。手术时间为305分钟,失血200毫升。患者住院16天后出院,无手术并发症。组织学分析显示无尿路上皮癌(pT0N0)伴播散性癌。术后7个月,未观察到复发或远处/淋巴结转移迹象。未报告膀胱完全排空时的尿漏情况。血清肌酐清除率为51毫升/分钟。术后免疫抑制方案未调整。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2664/11745229/04efca6259c5/rjaf009f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2664/11745229/04efca6259c5/rjaf009f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2664/11745229/04efca6259c5/rjaf009f1.jpg

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本文引用的文献

1
European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.欧洲泌尿外科学会肌层浸润性和转移性膀胱癌指南:2023 年指南摘要。
Eur Urol. 2024 Jan;85(1):17-31. doi: 10.1016/j.eururo.2023.08.016. Epub 2023 Oct 17.
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Robot-Assisted Radical Cystectomy With Orthotopic Neobladder as a Urinary Diversion for a Kidney Transplant Recipient: A Case Report.机器人辅助根治性膀胱切除术联合原位新膀胱术用于肾移植受者尿液转流:1例病例报告
Transplant Proc. 2020 Mar;52(2):608-613. doi: 10.1016/j.transproceed.2019.12.002. Epub 2020 Feb 19.
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Pure intracorporeal laparoscopic radical cystectomy with orthotopic "U" shaped ileal neobladder.采用原位“U”形回肠新膀胱的纯腹腔镜体内根治性膀胱切除术。
BMC Urol. 2014 Nov 18;14:89. doi: 10.1186/1471-2490-14-89.
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Am J Transplant. 2003 Sep;3(9):1128-34. doi: 10.1034/j.1600-6143.2003.00185.x.