Wu Jing, Chen Yingyao, Xie Mengqing, Yu Xin, Su Chunxia
Department of Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China.
Chin Med J Pulm Crit Care Med. 2024 Dec 12;2(4):257-264. doi: 10.1016/j.pccm.2024.11.001. eCollection 2024 Dec.
The innate immune system has a primary role in defending against external threats, encompassing viruses, bacteria, and fungi, thereby playing a pivotal role in establishing robust protection. Recent investigations have shed light on its importance in the progression of tumors, with a particular emphasis on lung cancer. Among the various signaling pathways implicated in this intricate process, the cGAS-STING pathway emerges as a significant participant. Cyclic GMP-AMP synthase (cGAS) discerns free DNA and activates the stimulator of interferon genes (STING), subsequently culminating in the secretion of cytokines and exerting inhibitory effects on tumor development. Consequently, researchers are increasingly interested in creating anticancer drugs that specifically target the cGAS-STING pathway, offering promising avenues for novel therapeutic interventions. The objective of this review is to present a comprehensive overview of the ongoing research on the cGAS-STING signaling pathway within the realm of lung cancer. The primary emphasis is on understanding its involvement in lung cancer development and assessing its viability as a target for innovative therapeutic options.
先天性免疫系统在抵御外部威胁（包括病毒、细菌和真菌）方面发挥着主要作用，从而在建立强大的保护机制中起着关键作用。最近的研究揭示了其在肿瘤进展中的重要性，尤其是在肺癌方面。在这个复杂过程中涉及的各种信号通路中，cGAS-STING通路成为一个重要参与者。环状GMP-AMP合酶（cGAS）识别游离DNA并激活干扰素基因刺激物（STING），随后最终导致细胞因子的分泌，并对肿瘤发展产生抑制作用。因此，研究人员越来越有兴趣开发专门针对cGAS-STING通路的抗癌药物，为新型治疗干预提供了有前景的途径。本综述的目的是全面概述肺癌领域中关于cGAS-STING信号通路的正在进行的研究。主要重点是了解其在肺癌发展中的作用，并评估其作为创新治疗选择靶点的可行性。
