Ozturk Huseyin Ali, Arici Fatih Necip
Department of Internal Medicine, University of Health Sciences-Adana Health Practice and Research Center, Adana, Turkey.
PeerJ. 2025 Jan 17;13:e18606. doi: 10.7717/peerj.18606. eCollection 2025.
Optimal treatment of the coronavirus disease (COVID-19) is still unclear. It has been reported that the use of different doses of corticosteroid treatments may reduce mortality. In our study, we aimed to find the effect of corticosteroid treatment dose on mortality of patients followed up in intensive care due to COVID-19.
Our retrospective, descriptive and single-centre study included 102 patients diagnosed with COVID-19 who were followed up in intensive care unit, 28 of whom received pulse steroids and 74 of whom received high dose steroids. Laboratory values, duration of intensive care unit and mortality rates of the patients were evaluated.
Mortality was found to be statistically significantly lower in the group receiving pulse steroid compared to the group receiving high dose steroid. In multivariate logistic regression analysis, age and pulse steroid were found to be independent predictors of mortality. According to this analysis, each 10-year increase in age increased mortality by 4.8%, whereas pulse steroid decreased mortality by 79.4%.
In our study, we found that mortality was statistically significantly lower in the group of patients receiving pulse steroids than in the group receiving high dose steroids. We found that the number of patients using pulse steroids was statistically significantly lower in the group with mortality. We found that age and pulse steroid independently determined the patients with mortality.
冠状病毒病（COVID-19）的最佳治疗方法仍不明确。据报道，使用不同剂量的皮质类固醇治疗可能会降低死亡率。在我们的研究中，我们旨在探讨皮质类固醇治疗剂量对因COVID-19在重症监护室接受随访患者死亡率的影响。
我们的回顾性、描述性单中心研究纳入了102例在重症监护室接受随访的COVID-19确诊患者，其中28例接受了冲击剂量类固醇治疗，74例接受了高剂量类固醇治疗。评估了患者的实验室检查值、重症监护室住院时间和死亡率。
发现接受冲击剂量类固醇治疗的组死亡率在统计学上显著低于接受高剂量类固醇治疗的组。在多因素逻辑回归分析中，年龄和冲击剂量类固醇被发现是死亡率的独立预测因素。根据该分析，年龄每增加10岁，死亡率增加4.8%，而冲击剂量类固醇可使死亡率降低79.4%。
在我们的研究中，我们发现接受冲击剂量类固醇治疗的患者组死亡率在统计学上显著低于接受高剂量类固醇治疗的组。我们发现死亡组中使用冲击剂量类固醇的患者数量在统计学上显著更低。我们发现年龄和冲击剂量类固醇独立决定了死亡患者。
