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硝酸银局部治疗脐肉芽肿致化学性烧伤：1例报告

Chemical Burns Caused by Topical Silver Nitrate in Umbilical Granuloma Treatment: A Case Report.

作者信息

Saleem Muhammad M, Pervaiz Mishal, Mazhar Ismail, Shoaib Uswah, Tahir Muhammad Ibrahim, Ahmad Haseeb, Khauteja Khan Sehar, Sami Khawaja Haider

机构信息

General and Pediatric Surgery, Combined Military Hospital (CMH), Lahore, PAK.

Anesthesiology, Combined Military Hospital (CMH), Lahore, PAK.

出版信息

Cureus. 2024 Dec 19;16(12):e76041. doi: 10.7759/cureus.76041. eCollection 2024 Dec.

DOI:10.7759/cureus.76041
PMID:39835013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11743746/
Abstract

An umbilical granuloma (UG) is one of the most common umbilical anomalies seen in infants, mostly due to delayed cord separation. It is usually treated with silver nitrate; however, topical application of silver nitrate can cause chemical burns, creating concern among parents. We present a similar case in a two-month-old baby boy with a giant UG, which was treated with topical silver nitrate application, producing significant chemical burns around the umbilicus and on the anterior abdominal wall. The patient was treated conservatively with a good outcome.

摘要

脐肉芽肿（UG）是婴儿中最常见的脐部异常之一，主要是由于脐带延迟脱落。通常用硝酸银治疗；然而，局部应用硝酸银会导致化学灼伤，这引起了家长们的担忧。我们报告了一名两个月大男婴患有巨大脐肉芽肿的类似病例，该病例采用局部应用硝酸银治疗，导致脐周和前腹壁出现严重化学灼伤。该患者接受了保守治疗，效果良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3329/11743746/1595e3de3c9c/cureus-0016-00000076041-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3329/11743746/658f1bc56c88/cureus-0016-00000076041-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3329/11743746/9ba77ad87bc9/cureus-0016-00000076041-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3329/11743746/1595e3de3c9c/cureus-0016-00000076041-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3329/11743746/658f1bc56c88/cureus-0016-00000076041-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3329/11743746/9ba77ad87bc9/cureus-0016-00000076041-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3329/11743746/1595e3de3c9c/cureus-0016-00000076041-i03.jpg

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1
Chemical Burns Caused by Topical Silver Nitrate in Umbilical Granuloma Treatment: A Case Report.硝酸银局部治疗脐肉芽肿致化学性烧伤：1例报告
Cureus. 2024 Dec 19;16(12):e76041. doi: 10.7759/cureus.76041. eCollection 2024 Dec.
2
Silver nitrate burns following treatment for umbilical granuloma.硝酸银治疗脐肉芽肿后发生灼伤。
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Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial.硝酸银治疗与局部类固醇治疗脐肉芽肿的非劣效性随机对照试验。
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Treating umbilical granuloma with topical clobetasol propionate cream at home is as effective as treating it with topical silver nitrate in the clinic.在家使用丙酸氯倍他索乳膏治疗脐肉芽肿与在诊所使用硝酸银局部治疗同样有效。
Acta Paediatr. 2015 Feb;104(2):174-7. doi: 10.1111/apa.12824. Epub 2014 Nov 4.
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Silver nitrate burns following treatment for umbilical granuloma.硝酸银烧灼治疗脐肉芽肿后。
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Silver nitrate burns following umbilical granuloma treatment.硝酸银烧灼用于脐肉芽肿治疗后。
Arch Dis Child. 2005 Jul;90(7):674. doi: 10.1136/adc.2004.067918.
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[Skin corrosions in infants after silver nitrate treatment in umbilical granuloma].[硝酸银治疗脐肉芽肿后婴儿的皮肤腐蚀]
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引用本文的文献

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Clinical analysis of 25 cases of infant umbilical granuloma treated with topical application of common salt granules.25例婴幼儿脐肉芽肿应用食盐颗粒外敷治疗的临床分析
Front Pediatr. 2025 Jul 31;13:1592198. doi: 10.3389/fped.2025.1592198. eCollection 2025.

本文引用的文献

1
Common Salt versus Silver Nitrate for the Treatment of Umbilical Granuloma in Infants: An Open-label, Single-center, Pilot Randomized Controlled Trial.普通食盐与硝酸银治疗婴儿脐肉芽肿：一项开放标签、单中心、先导性随机对照试验
J Indian Assoc Pediatr Surg. 2024 May-Jun;29(3):199-203. doi: 10.4103/jiaps.jiaps_209_23. Epub 2024 May 8.
2
Umbilical Granuloma: Frequency, Associated Factors, 10-Year Treatment Trends, and Effectiveness at a Single Hospital in Japan.脐肉芽肿：日本一家医院的发病率、相关因素、10年治疗趋势及疗效
J Clin Med. 2023 Sep 21;12(18):6104. doi: 10.3390/jcm12186104.
3
Silver nitrate burns following umbilical granuloma treatment.
硝酸银烧灼用于脐肉芽肿治疗后。
Pediatr Neonatol. 2024 Jan;65(1):94-95. doi: 10.1016/j.pedneo.2023.06.004. Epub 2023 Aug 25.
4
Treatment of Umbilical Granuloma in Infants With Topical Application of Common Salt: A Scoping Review.应用食盐局部治疗婴儿脐肉芽肿：系统评价。
J Pediatr Surg. 2023 Sep;58(9):1843-1848. doi: 10.1016/j.jpedsurg.2023.03.007. Epub 2023 Mar 15.
5
Umbilical granuloma frequency of newborns in Third-line Hospital in Turkey.土耳其三线医院新生儿脐肉芽肿的发生频率。
Afr Health Sci. 2022 Jun;22(2):560-564. doi: 10.4314/ahs.v22i2.64.
6
Management of umbilical granuloma in infants: A systematic review of randomised controlled trials.婴儿脐肉芽肿的管理：随机对照试验的系统评价
Aust J Gen Pract. 2021 Aug;50(8):589-594. doi: 10.31128/AJGP-04-20-5371.
7
Umbilical Lesions: A Cluster of Known Unknowns and Unknown Unknowns.脐部病变：一系列已知的未知与未知的未知
Cureus. 2019 Aug 2;11(8):e5309. doi: 10.7759/cureus.5309.
8
[Skin corrosions in infants after silver nitrate treatment in umbilical granuloma].[硝酸银治疗脐肉芽肿后婴儿的皮肤腐蚀]
Ugeskr Laeger. 2016 Apr 18;178(16):V67434.
9
Treating umbilical granuloma with topical clobetasol propionate cream at home is as effective as treating it with topical silver nitrate in the clinic.在家使用丙酸氯倍他索乳膏治疗脐肉芽肿与在诊所使用硝酸银局部治疗同样有效。
Acta Paediatr. 2015 Feb;104(2):174-7. doi: 10.1111/apa.12824. Epub 2014 Nov 4.
10
Silver nitrate burns following umbilical granuloma treatment.硝酸银烧灼用于脐肉芽肿治疗后。
Arch Dis Child. 2005 Jul;90(7):674. doi: 10.1136/adc.2004.067918.