Factors Associated With the Development of Heart Failure Following Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.

Acute coronary syndrome (ACS) remains a major global health burden, encompassing a spectrum of conditions from unstable angina to acute myocardial infarction. Despite advancements in early detection and management, ACS is often complicated by the development of heart failure. This systematic review and meta-analysis aimed to identify factors associated with the development of heart failure following acute coronary syndrome. A comprehensive search was conducted across PubMed, Embase, Cochrane Library, and Web of Science from January 2018 to November 2024. Studies evaluating clinical or biochemical predictors of heart failure development in adult patients with acute coronary syndrome were included. Out of the initially identified studies, nine studies met the inclusion criteria. The Newcastle-Ottawa Scale was used to assess the quality of included studies, with most studies demonstrating high quality. The pooled analysis revealed that older age, female sex, diabetes, hypertension, chronic obstructive pulmonary disease, atrial fibrillation, multivessel coronary disease, and reduced left ventricular ejection fraction were significant predictors of heart failure development following acute coronary syndrome. The presence of atrial fibrillation emerged as the strongest predictor, followed by reduced left ventricular ejection fraction and chronic obstructive pulmonary disease. While complete revascularization showed a protective trend, this association did not reach statistical significance. The findings were limited by the predominantly retrospective nature of included studies and heterogeneity in the assessment of certain risk factors. Future research should focus on prospective studies with larger cohorts and comprehensive evaluation of additional factors such as treatment delays and revascularization strategies. Understanding these predictors can facilitate early risk stratification and guide targeted interventions, potentially improving outcomes for patients with acute coronary syndrome.