Franson T R, Hierholzer W J, LaBrecque D R
Rev Infect Dis. 1985 Jan-Feb;7(1):1-9. doi: 10.1093/clinids/7.1.1.
One hundred consecutive patients with blood cultures positive for microbial growth were prospectively surveyed for the presence of hepatic abnormalities and clinical evidence of infection. Complete data for 82 patients were available for analysis. Fifty-four percent had elevated bilirubin levels, and 34% had total bilirubin values of greater than or equal to 2.0 mg/dl. The levels of total bilirubin were disproportionately elevated compared with those of aspartate aminotransferase, alkaline phosphatase, and cholesterol. Nine of the 23 patients with elevated bilirubin levels had an increase in serum bilirubin one to nine days before their initial positive blood culture. Disproportionate elevations of direct and total serum bilirubin values compared with values for other liver-function tests appear to be associated with bacteremia in adults more frequently than previously recognized and may have some predictive value in such patients.
对100例血培养微生物生长呈阳性的连续患者进行前瞻性调查，以了解其肝脏异常情况和感染的临床证据。82例患者的完整数据可供分析。54%的患者胆红素水平升高，34%的患者总胆红素值大于或等于2.0mg/dl。与天冬氨酸转氨酶、碱性磷酸酶和胆固醇相比，总胆红素水平升高幅度不成比例。23例胆红素水平升高的患者中有9例在首次血培养阳性前1至9天血清胆红素升高。与其他肝功能检查值相比，直接和总血清胆红素值不成比例升高似乎比以前认识到的更频繁地与成人菌血症相关，并且可能对此类患者具有一定的预测价值。
