Keller R, Ragaz A, Monard D, Siebenschein R, Hildebrand P
Schweiz Med Wochenschr. 1985 Mar 9;115(10):334-41.
The effect of home long-term oxygen therapy has been evaluated in 70 patients (52 men and 18 women) with chronic respiratory insufficiency due to chronic obstructive pulmonary disease. The mean duration of the observation period was 17.5 months, lasting at least 6 months and in a few cases over 40 months. The cumulative death rate was 22.6% in the first 12 months, 36.5% after two years and 40.7% in the third year. Compared to a previous period of 19.5 months there was an obvious reversal in hypoxemia, an increase in physical capacity and a reduction in the hospitalization rate. Patients with marked respiratory failure and with the clinical features of the "blue bloater" type of chronic bronchitis responded better to the home oxygen therapy than a group of "advanced pink puffers" with hypercapnia and high pulmonary arterial pressure. The present results do however confirm the beneficial effects of long-term domiciliary oxygen administration, and should encourage critical use of this new therapeutic regimen according to the indications so far recommended.
对70例（52例男性和18例女性）因慢性阻塞性肺疾病导致慢性呼吸功能不全的患者进行了家庭长期氧疗效果评估。观察期平均持续17.5个月，至少持续6个月，少数病例超过40个月。前12个月累积死亡率为22.6%，两年后为36.5%，第三年为40.7%。与之前19.5个月的时期相比，低氧血症明显改善，体能增加，住院率降低。有明显呼吸衰竭且具有“蓝肿型”慢性支气管炎临床特征的患者，比一组有高碳酸血症和高肺动脉压的“晚期红喘型”患者对家庭氧疗反应更好。然而，目前的结果确实证实了长期家庭氧疗的有益效果，应鼓励根据目前推荐的适应症谨慎使用这种新的治疗方案。
