Fang Xiaobin, Mo Chunheng, Zheng Ling, Gao Fei, Xue Fu-Shan, Zheng Xiaochun
Department of Anesthesiology/Critical Care Medicine, Fuzhou University Affiliated Provincial Hospital, School of Medicine, Fuzhou University, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Key Laboratory of Critical Care Medicine, Fujian Provincial Hospital, Fuzhou, Fujian, 350001, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Adv Sci (Weinh). 2025 Mar;12(11):e2413364. doi: 10.1002/advs.202413364. Epub 2025 Jan 21.
Transfusion-related acute lung injury (TRALI) is a potentially lethal complication of blood transfusions, characterized by the rapid onset of pulmonary edema and hypoxemia within six hours post-transfusion. As one of the primary causes of transfusion-related mortality, TRALI carries a significant mortality rate of 6-12%. However, effective treatment strategies for TRALI are currently lacking, underscoring the urgent need for a comprehensive and in-depth understanding of its pathogenesis. This comprehensive review provides an updated and detailed analysis of the current landscape of TRALI, including its clinical presentation, pathogenetic hypotheses, animal models, cellular mechanisms, signaling pathways, and potential therapeutic targets. By highlighting the critical roles of these pathways and therapies, this review offers valuable insights to inform the development of preventative and therapeutic strategies and to guide future research efforts aimed at addressing this life-threatening condition.
输血相关急性肺损伤（TRALI）是输血的一种潜在致命并发症，其特征为输血后6小时内迅速出现肺水肿和低氧血症。作为输血相关死亡的主要原因之一，TRALI的死亡率高达6-12%。然而，目前缺乏针对TRALI的有效治疗策略，这凸显了全面深入了解其发病机制的迫切需求。本综述对TRALI的现状进行了更新和详细分析，包括其临床表现、发病机制假说、动物模型、细胞机制、信号通路以及潜在治疗靶点。通过强调这些途径和疗法的关键作用，本综述提供了有价值的见解，为预防和治疗策略的制定提供参考，并指导未来旨在解决这一危及生命状况的研究工作。
