Huang Haoyan, Ren Jie, Liu Guang-Hui
National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Key Laboratory of RNA Science and Engineering, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Aging Biomarker Consortium (ABC), Beijing 100101, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China; School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
Curr Opin Genet Dev. 2025 Apr;91:102306. doi: 10.1016/j.gde.2024.102306. Epub 2025 Jan 20.
Aging is a systemic, complex, and heterogeneous process characterized by a progressive decline in physiological functions, rendering it a major risk factor for various chronic diseases. Chronic inflammation has emerged as both a hallmark and a driver in this complicated process. This persistent inflammatory state arises from a spectrum of stimuli, ranging from external pathogens to internal cellular remnants, to metabolic dysregulation, and to chronic stress. Here, we examine recent mechanistic advances into the driving forces behind age-related chronic inflammation, explore promising anti-inflammatory strategies to mitigate aging, and address current challenges, proposing future directions to propel this evolving field toward translational breakthrough.
衰老 是一个系统性、复杂且异质性的过程，其特征是生理功能逐渐衰退，使其成为各种慢性疾病的主要风险因素。慢性炎症已成为这一复杂过程的一个标志和驱动因素。这种持续的炎症状态源于一系列刺激，从外部病原体到内部细胞残余物，再到代谢失调以及慢性应激。在此，我们研究了与年龄相关的慢性炎症背后驱动因素的最新机制进展，探索了有前景的抗炎策略以减轻衰老，并应对当前挑战，提出未来方向，推动这一不断发展的领域实现转化突破。
