神经系统疾病可通过相分离来调节。
Neurological Diseases can be Regulated by Phase Separation.
作者信息
McCaig Colin D
机构信息
Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK.
出版信息
Rev Physiol Biochem Pharmacol. 2025;187:273-338. doi: 10.1007/978-3-031-68827-0_16.
PMID:39838017
Abstract
Several neurological diseases arise from abnormal protein aggregation within neurones and this is closely regulated by phase separation. One such is motor neurone disease and aberrant aggregation of superoxide dismutase. Again these events are regulated by electrical forces that are examined.
摘要
几种神经系统疾病源于神经元内异常的蛋白质聚集，而这一过程受相分离的严格调控。运动神经元病和超氧化物歧化酶的异常聚集就是其中的例子。同样，这些过程受所研究的电力调控。
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