KLF15在小鼠小脑中的分布及功能意义

Li Dan, Cao Shuijing, Chen Yanrong, Liu Yueyan, Huo Kugeng, Shi Zhuangqi, Han Shuxin, Wang Liecheng

Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, China.

Department of Basic Medicine, Department of Clinical Medicine, West Anhui Health Vocational College, Liuan, Anhui, 237000, China.

Mol Brain. 2025 Jan 21;18(1):3. doi: 10.1186/s13041-025-01172-3.

Kruppel-like factor 15 (KLF15), a member of the KLF family, is closely involved in many biological processes. However, the mechanism by which KLF15 regulates neural development is still unclear. Considering the complexity and importance of neural network development, in this study, we investigated the potent regulatory role of KLF15 in neural network development. KLF15 was detected highly expressed in the cerebellum and enriched in Purkinje cells, with a significant increase in KLF15 expression between 15 and 20 days of neural development. Knockdown of KLF15 led to loss of Purkinje cells and impaired motility in mice. Therefore, our study aims to elucidate the relationship between KLF15 and Purkinje cells in mice, may provide a new research idea for the developmental mechanism of the mouse cerebellum.

Kruppel样因子15（KLF15）是KLF家族的成员之一，密切参与许多生物学过程。然而，KLF15调节神经发育的机制仍不清楚。鉴于神经网络发育的复杂性和重要性，在本研究中，我们调查了KLF15在神经网络发育中的潜在调节作用。检测到KLF15在小脑中高表达，并在浦肯野细胞中富集，在神经发育的15至20天期间KLF15表达显著增加。敲低KLF15导致小鼠浦肯野细胞丢失和运动能力受损。因此，我们的研究旨在阐明小鼠中KLF15与浦肯野细胞之间的关系，可能为小鼠小脑的发育机制提供新的研究思路。