Smagin V G, Ivanikov I O, Vinogradov V A, Chorbinskaia S A
Ter Arkh. 1985;57(1):78-80.
The authors describe the results of studying basal gastrin secretion in patients with peptic ulcer of the duodenum at different phases of disease treated in 3 stages. It was revealed that basal secretion of gastrin experienced substantial changes in the course of transition from the phase of exacerbation to the phase of disease remission. It was noted that the onset of the clinico-endoscopic remission of peptic ulcer did not correlate in all the cases with normalization of basal gastrin level. Patients who did not show normalization of basal gastrin level during treatment were more prone to the development of repeated exacerbations. Based on the data obtained the authors determined the prognostic importance of radioimmunoassay of gastrin basal concentration over time. The increment of gastrin concentration by more than 35 pg/ml of the level seen during peptic ulcer exacerbation is a prognostically unfavourable sign, for the probability of relapses rises up to 79% during a year.
作者描述了对十二指肠消化性溃疡患者在疾病不同阶段分三个阶段治疗时基础胃泌素分泌情况的研究结果。结果显示，从疾病加重期过渡到缓解期的过程中，胃泌素的基础分泌发生了显著变化。值得注意的是，消化性溃疡临床内镜缓解的起始在所有病例中并非都与基础胃泌素水平的正常化相关。治疗期间基础胃泌素水平未恢复正常的患者更容易出现疾病复发。基于所获得的数据，作者确定了随时间对胃泌素基础浓度进行放射免疫测定的预后重要性。与消化性溃疡加重期相比，胃泌素浓度升高超过35 pg/ml是一个预后不良的迹象，因为一年内复发的概率会升至79%。
