Shvarts V Ia, Kuznetsov B G, Frolkov V K, Saakian A G
Ter Arkh. 1984;56(8):97-100.
It has been demonstrated that the basal gastrin level in the blood of patients with peptic ulcer of the duodenum is similar to that in normal subjects. Food stimulation raises blood gastrin in normal subjects and patients. However, in patients, the peak of the blood hormone rise is higher, with this rise lasting for a longer time. Besides, the total output of the hormone is greater. These changes are most marked during an incomplete disease remission, being less remarkable when exacerbation gets attenuated and during a complete remission. A correlation has been noticed between the acid-forming function of the stomach and basal blood gastrin level that increases as the acid content in gastric juice descends. In patients experiencing a complete remission and in those in the stage of an incomplete remission and attenuated exacerbation, a direct correlation was ascertained between the stimulated hypergastrinemia and duration of the intragastral pH elevation in response to food intake. It is suggested that in peptic ulcer of the duodenum, hypergastrinemia occurs as a defence reaction aimed at the activation of trophic processes in the mucous membrane of the gastroduodenal zone.
已证实十二指肠消化性溃疡患者血液中的基础胃泌素水平与正常受试者相似。食物刺激会使正常受试者和患者的血液胃泌素升高。然而，在患者中，血液激素升高的峰值更高，且这种升高持续时间更长。此外，激素的总分泌量更大。这些变化在疾病不完全缓解期间最为明显，在病情加重减轻和完全缓解时则不太显著。已注意到胃的产酸功能与基础血液胃泌素水平之间存在相关性，随着胃液中酸含量的下降，基础血液胃泌素水平会升高。在完全缓解的患者以及不完全缓解和病情加重减轻阶段的患者中，已确定刺激后的高胃泌素血症与进食后胃内pH升高的持续时间之间存在直接相关性。有人认为，在十二指肠消化性溃疡中，高胃泌素血症是一种防御反应，旨在激活胃十二指肠区域黏膜的营养过程。
