Morinobu Miki, Tsuchiya Akira, Shimabukuro Masaya, Moriyama Masafumi, Ishikawa Kunio
Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Langmuir. 2025 Feb 4;41(4):2892-2898. doi: 10.1021/acs.langmuir.4c04782. Epub 2025 Jan 21.
Titanium alloy plates are often used for fixation to bone. However, the plates often need to be removed due to infection and adverse inflammation. To avoid these problems, we immobilized copper, which has antibacterial effects and low cytotoxicity, on titanium plates by immersing the titanium in copper-tris(hydroxymethyl)aminomethane complex solutions. The amount of copper immobilized on the titanium alloy surface was dependent on the amount of tris(hydroxymethyl)aminomethane and the pH of the solutions. The maximum amount of copper immobilized on the titanium alloy surface was about 20 atomic%, without any change in the surface morphological characteristics. The obtained titanium alloy with immobilized copper exhibited antibacterial and anti-inflammation properties without cytotoxicity.
钛合金板常用于固定骨骼。然而，由于感染和不良炎症，这些板子常常需要移除。为避免这些问题，我们通过将钛浸入三（羟甲基）氨基甲烷铜络合物溶液中，将具有抗菌作用且细胞毒性低的铜固定在钛板上。固定在钛合金表面的铜量取决于三（羟甲基）氨基甲烷的量和溶液的pH值。固定在钛合金表面的铜的最大量约为20原子%，表面形态特征没有任何变化。所获得的固定有铜的钛合金表现出抗菌和抗炎特性，且无细胞毒性。
