Xu Zhehao, Ding Jia, Liang Ruiyun, Xie Shuangfeng
Department of General Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Hematology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Front Med (Lausanne). 2025 Jan 7;11:1502916. doi: 10.3389/fmed.2024.1502916. eCollection 2024.
Pulmonary arterial hypertension (PAH) poses a significant health challenge globally, with China experiencing a notable increase in its burden. Understanding the trends and factors contributing to PAH is crucial for developing effective public health strategies.
This study utilized data from the Global Burden of Disease (GBD) 2021 database to estimate the burden of PAH in China and worldwide from 1990 to 2021. A Bayesian age-period-cohort (BAPC) model was employed to analyze differences in PAH burden across age, gender, and time periods, and to project global epidemiological trends until 2036.
From 1990 to 2021, the incidence and prevalence of PAH in China increased by 80.59% and 86.74%, respectively. The age-standardized incidence rate (ASIR) and age-standardized prevalence rate (ASPR) showed an annual percentage change (AAPC) of -0.07% and 0.25%, respectively. Conversely, the age-standardized disability-adjusted life year (DALY) rate and age-standardized mortality rate (ASMR) have been declining since 1990, with AAPC of -1.90% and -1.26%, respectively. Females and the 50-70 years age group experienced a higher PAH burden compared to males. Projections indicate that ASPR, ASMR, and age-standardized death rate (ASDR) will stabilize with minimal variation over the next decade.
The findings highlight the age-related burden of PAH in China, particularly affecting older populations and women. The projected stabilization of PAH metrics over the next decade underscores the need for continued monitoring and targeted interventions. This study's comprehensive analysis of PAH burden over three decades provides valuable insights for policymakers and healthcare providers, necessitating concerted efforts to address this critical health issue.
肺动脉高压（PAH）在全球范围内对健康构成重大挑战，中国的疾病负担显著增加。了解PAH的发展趋势和影响因素对于制定有效的公共卫生策略至关重要。
本研究利用全球疾病负担（GBD）2021数据库的数据，估计1990年至2021年中国和全球PAH的疾病负担。采用贝叶斯年龄-时期-队列（BAPC）模型分析PAH负担在年龄、性别和时间段上的差异，并预测到2036年的全球流行病学趋势。
1990年至2021年，中国PAH的发病率和患病率分别上升了80.59%和86.74%。年龄标准化发病率（ASIR）和年龄标准化患病率（ASPR）的年百分比变化（AAPC）分别为-0.07%和0.25%。相反，自1990年以来，年龄标准化残疾调整生命年（DALY）率和年龄标准化死亡率（ASMR）一直在下降，AAPC分别为-1.90%和-1.26%。与男性相比，女性和50-70岁年龄组的PAH负担更高。预测表明，在未来十年中，ASPR、ASMR和年龄标准化死亡率（ASDR）将趋于稳定，变化极小。
研究结果凸显了中国PAH与年龄相关的负担，尤其对老年人群体和女性影响较大。预计未来十年PAH指标将趋于稳定，这突出了持续监测和针对性干预的必要性。本研究对三十年来PAH负担的全面分析为政策制定者和医疗服务提供者提供了宝贵的见解，需要各方共同努力应对这一关键的健康问题。
