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脑死亡的辅助检查

Ancillary tests for brain death.

作者信息

Duvuru Shyam, Sanker Vivek, Mishra Rajeeb Kumar, Sharma Arvind K, Lim Shir Lynn, Baskar Nisha, Sharma Vijay K

机构信息

Apollo Specialty Hospital, Madurai, India.

National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.

出版信息

Front Neurol. 2025 Jan 7;15:1491263. doi: 10.3389/fneur.2024.1491263. eCollection 2024.

DOI:10.3389/fneur.2024.1491263
PMID:39839883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11747481/
Abstract

BACKGROUND

Ancillary tests are often used in the determination of death by neurologic criteria (DNC), especially when the clinical examination is inconclusive. DNC is widely accepted, as defined by the comprehensive report of the World Brain Death Project. However, there are several medical, legal, religious, ethical, and social controversies. Accordingly, "premature" and "delayed" diagnoses of brain death attract these issues.

METHODS

Depending upon the availability and experience of the managing medical teams, various ancillary tests are employed for an early and supplementary diagnosis of brain death.

RESULTS

We describe the practicality, test performance, and utility of some of the commonly employed ancillary tests for the diagnosis of brain death in clinical practice, along with their case examples.

CONCLUSION

Brain death is a clinical diagnosis determined by history, physical examination, and adherence to recommended criteria. All ancillary investigations are used as supplementary tests with variable accuracy parameters. These ancillary tests often facilitate an early and "timely" diagnosis of brain death.

摘要

背景

辅助检查常用于依据神经学标准判定死亡(DNC),尤其是在临床检查结果不明确时。如世界脑死亡项目综合报告所定义,DNC已被广泛接受。然而,存在一些医学、法律、宗教、伦理和社会方面的争议。因此,脑死亡的“过早”和“延迟”诊断引发了这些问题。

方法

根据管理医疗团队的可及性和经验,采用各种辅助检查对脑死亡进行早期和补充诊断。

结果

我们描述了临床实践中一些常用辅助检查用于诊断脑死亡的实用性、检测性能和效用,并列举了病例实例。

结论

脑死亡是一种由病史、体格检查及遵循推荐标准所确定的临床诊断。所有辅助检查都用作具有不同准确性参数的补充检查。这些辅助检查常常有助于脑死亡的早期和“及时”诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/4a09e7c2ea6a/fneur-15-1491263-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/7d245b9f073d/fneur-15-1491263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/429681eb6b93/fneur-15-1491263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/2dfcb5b390b1/fneur-15-1491263-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/32896ff55586/fneur-15-1491263-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/9335411396a6/fneur-15-1491263-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/4a09e7c2ea6a/fneur-15-1491263-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/7d245b9f073d/fneur-15-1491263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/429681eb6b93/fneur-15-1491263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/2dfcb5b390b1/fneur-15-1491263-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/32896ff55586/fneur-15-1491263-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/9335411396a6/fneur-15-1491263-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/11747481/4a09e7c2ea6a/fneur-15-1491263-g006.jpg

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本文引用的文献

1
The 2023 AAN/AAP/CNS/SCCM Pediatric and Adult Brain Death/Death by Neurologic Criteria Consensus Practice Guideline: A Comparison With the 2010 and 2011 Guidelines.《2023年美国神经病学学会/美国儿科学会/美国神经外科医师协会/危重病医学会儿科与成人大脑死亡/神经病学标准判定死亡共识实践指南:与2010年和2011年指南的比较》
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Diagnostic accuracy of ancillary tests for death by neurologic criteria: a systematic review and meta-analysis.辅助检查用于神经标准判定死亡的诊断准确性:系统评价和荟萃分析。
Can J Anaesth. 2023 Apr;70(4):736-748. doi: 10.1007/s12630-023-02426-1. Epub 2023 May 8.
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Ancillary investigations for death determination in infants and children: a systematic review and meta-analysis.
辅助检查在婴幼儿死亡判定中的应用:系统评价和荟萃分析。
Can J Anaesth. 2023 Apr;70(4):749-770. doi: 10.1007/s12630-023-02418-1. Epub 2023 May 2.
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Brain death: a clinical overview.脑死亡:临床概述。
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Flow is not perfusion, and perfusion is not function: ancillary testing for the diagnosis of brain death.血流并非灌注,灌注亦非功能:脑死亡诊断的辅助检查
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How should we use imaging in the determination of brainstem death?我们应如何利用影像学检查来判定脑死亡?
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JAMA. 2020 Sep 15;324(11):1078-1097. doi: 10.1001/jama.2020.11586.
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Ancillary Testing for Determination of Death by Neurologic Criteria Around the World.全球用于通过神经学标准确定死亡的辅助检测。
Neurocrit Care. 2021 Apr;34(2):473-484. doi: 10.1007/s12028-020-01039-6.
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