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二氯甲烷经皮肤接触导致一氧化碳中毒：一例报告

Carbon Monoxide Toxicity Secondary to Cutaneous Methylene Chloride Exposure: A Case Report.

作者信息

Dornbush Carine, Mohr William, Galet Colette, Wibbenmeyer Lucy, Kurjatko Alexander

机构信息

Department of Surgery, Division of Acute Care Surgery University of Iowa Iowa City Iowa USA.

出版信息

Clin Case Rep. 2025 Jan 20;13(1):e70141. doi: 10.1002/ccr3.70141. eCollection 2025 Jan.

DOI:10.1002/ccr3.70141
PMID:39839948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11746923/
Abstract

Cutaneous absorption of methylene chloride is rarely toxic. This case shows that it can lead to carboxyhemoglobinemia. Exposure to methylene chloride should warrant a carboxyhemoglobin check and oxygen support. Adequate decontamination and monitoring for symptoms in patients with greater cutaneous exposure due to persistent risks for toxicity are warranted.

摘要

二氯甲烷的皮肤吸收很少产生毒性。本病例表明它可导致碳氧血红蛋白血症。接触二氯甲烷应进行碳氧血红蛋白检查并给予氧气支持。对于因持续存在毒性风险而有较大皮肤接触的患者，应进行充分的去污处理并监测症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce46/11746923/b79f7e15179b/CCR3-13-e70141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce46/11746923/545802bda02a/CCR3-13-e70141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce46/11746923/b79f7e15179b/CCR3-13-e70141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce46/11746923/545802bda02a/CCR3-13-e70141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce46/11746923/b79f7e15179b/CCR3-13-e70141-g002.jpg

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本文引用的文献

1
Assessment of Methylene Chloride-Related Fatalities in the United States, 1980-2018.1980-2018 年美国与二氯甲烷相关的死亡评估。
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Methylene Chloride Burns: A Case Report and Review of Literature.二氯甲烷烧伤：一例病例报告及文献综述
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Blood carboxyhemoglobin elimination curve, half-lifetime, and arterial-venous differences in acute phase of carbon monoxide poisoning in ovine smoke inhalation injury model.
绵羊烟雾吸入性损伤模型一氧化碳中毒急性期血碳氧血红蛋白清除曲线、半减期及动静脉差。
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Acute and delayed toxicity from co-ingestion of methylene chloride and methanol.二氯甲烷与甲醇共同摄入引起的急性和迟发性毒性。
Toxicol Commun. 2019;3(1):79-84. doi: 10.1080/24734306.2019.1685222. Epub 2019 Nov 12.
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Methylene chloride exposure and carboxyhemoglobin levels in cabinetmakers.细木工中接触二氯甲烷与碳氧血红蛋白水平
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