Furuhashi Takeshi, Toda Kanako, Weckwerth Wolfram
NUS Environmental Research Institute, National University of Singapore, Singapore, Singapore.
Department of Oral Health Sciences, Health Sciences, Saitama Prefectural University, Koshigaya-shi, Japan.
Front Mol Biosci. 2025 Jan 7;11:1499104. doi: 10.3389/fmolb.2024.1499104. eCollection 2024.
Cancer is ranked as the top cause of premature mortality. Volatile organic compounds (VOCs) are produced from catalytic peroxidation by reactive oxygen species (ROS) and have become a highly attractive non-invasive cancer screening approach. For future clinical applications, however, the correlation between cancer hallmarks and cancer-specific VOCs requires further study. This review discusses and compares cellular metabolism, signal transduction as well as mitochondrial metabolite translocation in view of cancer evolution and the basic biology of VOCs production. Certain cancerous characteristics as well as the origin of the ROS removal system date back to procaryotes and early eukaryotes and share commonalities with non-cancerous proliferative cells. This calls for future studies on metabolic cross talks and regulation of the VOCs production pathway.
癌症是过早死亡的首要原因。挥发性有机化合物（VOCs）由活性氧（ROS）催化过氧化产生，已成为一种极具吸引力的非侵入性癌症筛查方法。然而，对于未来的临床应用而言，癌症特征与癌症特异性VOCs之间的相关性仍需进一步研究。本综述鉴于癌症演变和VOCs产生的基础生物学，讨论并比较了细胞代谢、信号转导以及线粒体代谢物转运。某些癌症特征以及ROS清除系统的起源可追溯到原核生物和早期真核生物，并且与非癌性增殖细胞具有共性。这就需要未来对VOCs产生途径的代谢相互作用和调控进行研究。
