Junli Wang, Zhihong Hao, Lina Wang, Qiaoqun Ou, Jing Qu, Jiaqi Hu, Yu Shengyou
Department of Pediatrics, The Second Affiliated Hospital, South China University of Technology, Guangzhou, China.
Department of Pediatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Front Pharmacol. 2025 Jan 7;15:1488340. doi: 10.3389/fphar.2024.1488340. eCollection 2024.
The glomerular podocyte endoplasmic reticulum is a critical component in renal function, yet its research landscape is not fully understood. This study aims to map the existing research on podocyte endoplasmic reticulum by analyzing publications in the Web of Science Core Collection (WOSCC) from the past 19 years.
We conducted a bibliometric analysis using Citespace, VOSviewer, the Metrology Literature Online platform, and the Bibliometrix software package to visualize and interpret the data from WOSCC. The analysis focused on publication volume, authorship, institutional contributions, and research trends.
The analysis revealed a significant growth in publications, indicating a surge in interest in podocyte endoplasmic reticulum research. Cybulsky, Andrey V, and Papillon, Joan emerge as the most prolific authors, and the Journal of the American Society of Nephrology is the leading journal in this field. China is the top contributor in terms of publications, with McGill University being the most productive institution. The research primarily focuses on endoplasmic reticulum stress, diabetic nephropathy, and apoptosis, with emerging trends in "foot cell apoptosis," "cell signaling pathways," and "autophagy."
The findings highlight the expanding scope of podocyte endoplasmic reticulum research, with a particular emphasis on the mechanisms of endoplasmic reticulum stress and podocyte apoptosis. Future research directions may include the identification of specific therapeutic targets, detailed exploration of podocyte signaling pathways, and the role of autophagy. This study provides a comprehensive overview of the major research areas, frontiers, and trends in podocyte endoplasmic reticulum research, which are pivotal for guiding future investigations.
肾小球足细胞内质网是肾功能的关键组成部分，但其研究现状尚未完全明晰。本研究旨在通过分析过去19年科学网核心合集（WOSCC）中的出版物，梳理足细胞内质网的现有研究情况。
我们使用Citespace、VOSviewer、计量学在线平台和Bibliometrix软件包进行文献计量分析，以可视化和解读来自WOSCC的数据。分析重点关注出版物数量、作者情况、机构贡献和研究趋势。
分析显示出版物数量显著增长，表明对足细胞内质网研究的兴趣激增。Cybulsky, Andrey V和Papillon, Joan是发文量最多的作者，《美国肾脏病学会杂志》是该领域的领先期刊。中国在出版物数量方面贡献最大，麦吉尔大学是产出最多的机构。研究主要集中在内质网应激、糖尿病肾病和细胞凋亡，“足细胞凋亡”“细胞信号通路”和“自噬”是新兴趋势。
研究结果凸显了足细胞内质网研究范围的不断扩大，尤其强调了内质网应激和足细胞凋亡的机制。未来的研究方向可能包括确定特定的治疗靶点、详细探索足细胞信号通路以及自噬的作用。本研究全面概述了足细胞内质网研究的主要领域、前沿和趋势，对指导未来研究至关重要。
