Asevedo Estéfani Alves, Ramos Santiago Livia, Kim Hyo Jeong, Syahputra Rony Abdi, Park Moon Nyeo, Ribeiro Rosy Iara Maciel Azambuja, Kim Bonglee
Experimental Pathology Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil.
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Front Pharmacol. 2025 Jan 7;15:1514573. doi: 10.3389/fphar.2024.1514573. eCollection 2024.
Herbal medicine are an invaluable reservoir of bioactive compounds, offering immense potential for novel drug development to address a wide range of diseases. Among these, has gained recognition for its historical medicinal applications and substantial therapeutic potential. This review explores the ethnopharmacological significance, phytochemical composition, and pharmacological properties of , with a particular focus on its anticancer activities. Traditionally, has been utilized for treating respiratory, gastrointestinal, and inflammatory conditions, demonstrating its broad therapeutic scope. The plant's rich array of bioactive compounds-flavonoids, triterpenoids, phenolic acids, and glycosides-forms the basis of its potent antioxidant, anti-inflammatory, and pharmacological effects. Modern pharmacological research has further substantiated its versatility, revealing anticancer, anti-diabetic, anti-infective, and hepatoprotective properties. However, significant challenges remain, including the need to unravel the precise molecular mechanisms underlying its anticancer effects, refine extraction and isolation methods for bioactive compounds, and validate its safety and efficacy through well-designed clinical trials. Particularly noteworthy is 's potential in combination therapies, where it may synergistically target multiple cancer pathways, enhance therapeutic outcomes, and mitigate adverse effects. This review synthesizes the findings from the past decade, providing a comprehensive evaluation of C. sappan's pharmacological promise while identifying critical areas for future research. By addressing these gaps, C. sappan could serve as a cornerstone for innovative therapeutic strategies, offering hope for improved management of cancer and other complex diseases.
草药是生物活性化合物的宝贵宝库，为开发治疗多种疾病的新型药物提供了巨大潜力。其中，[植物名称未给出]因其历史药用价值和巨大的治疗潜力而受到认可。本综述探讨了[植物名称未给出]的民族药理学意义、植物化学成分和药理特性，特别关注其抗癌活性。传统上，[植物名称未给出]一直用于治疗呼吸道、胃肠道和炎症性疾病，显示出其广泛的治疗范围。该植物丰富的生物活性化合物——黄酮类、三萜类、酚酸类和糖苷类——构成了其强大的抗氧化、抗炎和药理作用的基础。现代药理学研究进一步证实了其多功能性，揭示了其抗癌、抗糖尿病、抗感染和保肝特性。然而，仍存在重大挑战，包括需要阐明其抗癌作用背后的确切分子机制、完善生物活性化合物的提取和分离方法，以及通过精心设计的临床试验验证其安全性和有效性。特别值得注意的是[植物名称未给出]在联合治疗中的潜力，它可能协同作用于多种癌症途径，提高治疗效果，并减轻不良反应。本综述综合了过去十年的研究结果，对苏木的药理前景进行了全面评估，同时确定了未来研究的关键领域。通过填补这些空白，苏木可以成为创新治疗策略的基石，为改善癌症和其他复杂疾病的治疗带来希望。
