Mohamad Mustafa Muhammad 'Aqil Nazahah, Abdul Aziz Mohammad Faqis, Daud Adibah, Syed Abdul Rahman Sharifah Sakinah, Nordin Mohammad Hudzaifah, Zulkeflee Razan Hayati, Adzahar Sumaiyah
Department of Pathology and Medical Laboratory, Hospital Sultan Zainal Abidin, Kuala Terengganu, MYS.
Department of Pathology and Medical Laboratory, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS.
Cureus. 2024 Dec 18;16(12):e75975. doi: 10.7759/cureus.75975. eCollection 2024 Dec.
Lewis antibodies, such as anti-Le and anti-Le, are commonly encountered in routine immunohematology. They are typically IgM in nature and are generally considered clinically insignificant, as they rarely cause hemolytic transfusion reactions (HTRs) or hemolytic disease of the fetus and newborn (HDFN). However, rare cases have been reported where anti-Lewis antibodies caused mild transfusion reactions. In this case report, we describe a 69-year-old male with sepsis secondary to a neck carbuncle who was found to have clinically significant anti-Lewis antibodies. These antibodies presented a challenge during crossmatching, as only two out of seven units of packed red blood cells were compatible. This case underscores the importance of thorough pre-transfusion testing to ensure safe and effective blood transfusion practices.
刘易斯抗体，如抗-Lea和抗-Leb，在常规免疫血液学中很常见。它们本质上通常是IgM，一般被认为在临床上无显著意义，因为它们很少引起溶血性输血反应（HTR）或胎儿及新生儿溶血病（HDFN）。然而，已有罕见病例报道抗刘易斯抗体引起轻度输血反应。在本病例报告中，我们描述了一名69岁男性，因颈部痈继发败血症，被发现有具有临床意义的抗刘易斯抗体。这些抗体在交叉配血过程中带来了挑战，因为七单位浓缩红细胞中只有两单位与之相容。本病例强调了全面输血前检测对于确保安全有效的输血操作的重要性。
