Guru Aayushi, Singh Lal Pranay, Singh Nikita
Department of Pathology, Atal Bihari Vajpayee Government Medical College, Vidisha, IND.
Department of Pathology, Government Medical College Satna, Satna, IND.
Cureus. 2024 Dec 22;16(12):e76183. doi: 10.7759/cureus.76183. eCollection 2024 Dec.
Background Oral squamous cell carcinoma is a common problem among tobacco chewers and related products in developing countries like India. Histopathological examination evaluates and confirms the diagnosis of oral SCC. Clinical examination and molecular profiling by histopathological examination (HPE) are important prognostic tools used in clinical practice. Histopathological grade, depth of invasion, lymphovascular invasion, perineural invasion and necrosis are the factors routinely assessed in every case during clinical examination. Aim and objectives The present study aims to evaluate TP53 expression and correlate it with the histopathological parameters of oral squamous cell carcinoma. Materials and methods The present retrospective study was conducted in the histopathological section of the Department of Pathology, Atal Bihari Vajpayee Government Medical College, Vidisha, Madhya Pradesh. All the histopathologically diagnosed cases of oral squamous cell carcinoma from November 2023 to October 2024 were included in the study. The collected data were scored, and the immunopositivity of P53 was recorded and correlated with histopathological parameters. Results Oral SCC histopathology was reviewed retrospectively, and the association of histopathological features with P53 was discussed. A total number of 45 cases were included in the study. The most common age group was 41-50 years comprising 18 patients (40%), followed by the 31-40 years age group consisting of 12 patients (26%). According to histopathological parameters, they were graded, scored, and correlated with P53. A p-value <0.05 was considered statistically significant. Conclusion The initiating step in the treatment of patients with precancerous or malignant diseases in the oral cavity is accurate and timely diagnosis. The histopathological examination of suspicious oral lesions is currently the gold standard for diagnosis. The correct interpretation of biopsy, along with clinical and molecular evaluations, improves the prognosis. This study focuses on the importance of reporting various histopathological parameters of oral SCC.
背景
口腔鳞状细胞癌在印度等发展中国家是咀嚼烟草及相关产品人群中的常见问题。组织病理学检查用于评估和确诊口腔鳞状细胞癌。临床检查和通过组织病理学检查（HPE）进行的分子剖析是临床实践中重要的预后工具。组织病理学分级、浸润深度、脉管浸润、神经周围浸润和坏死是临床检查中每个病例常规评估的因素。
目的
本研究旨在评估TP53表达，并将其与口腔鳞状细胞癌的组织病理学参数相关联。
材料与方法
本回顾性研究在中央邦维迪沙市阿塔尔·比哈里·瓦杰帕伊政府医学院病理科的组织病理学切片中进行。纳入了2023年11月至2024年10月所有经组织病理学诊断为口腔鳞状细胞癌的病例。对收集的数据进行评分，记录P53的免疫阳性情况，并与组织病理学参数相关联。
结果
对口腔鳞状细胞癌的组织病理学进行了回顾性分析，并讨论了组织病理学特征与P53的关联。本研究共纳入45例病例。最常见的年龄组是41 - 50岁，有18例患者（40%），其次是31 - 40岁年龄组，有12例患者（26%）。根据组织病理学参数进行分级、评分，并与P53相关联。p值<0.05被认为具有统计学意义。
结论
口腔癌前或恶性疾病患者治疗的起始步骤是准确及时的诊断。可疑口腔病变的组织病理学检查目前是诊断的金标准。活检结果的正确解读以及临床和分子评估可改善预后。本研究着重于报告口腔鳞状细胞癌各种组织病理学参数的重要性。
