Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, India.
Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, India.
Pathol Res Pract. 2023 Nov;251:154882. doi: 10.1016/j.prp.2023.154882. Epub 2023 Oct 11.
Oral squamous cell carcinoma is one of the most common cancers of the head and neck region. Tumor-infiltrating lymphocytes are naturally occurring mononuclear cells that infiltrate the tumor microenvironment. The aim of the present study is the evaluation of stromal tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma and its association with clinicopathological parameters like age, gender, site, tumor stage, nodal status, grade, lymphovascular and perineural invasion.
A total of 51 patients of oral cavity squamous cell carcinomas who underwent resection were included in the study. Assessment of the stromal TILs was done on sections stained with Hematoxylin and eosin using the scoring criteria proposed by the International Immuno-Oncology Biomarker Working Group. TILs were assessed in percentages as continuous scores and subsequently categorized into low TILs (<20%) and high TILs (≥20%). The association between TILs and clinicopathological parameters was evaluated using the Fischer exact/Chi-square test.
Among the 51 cases evaluated in the present study, low and high TILs were found in 25.5% and 74.5% of cases respectively. TILs were found to show a significant association with tumor size and lymphovascular invasion. However, no significant association was found with age, gender, nodal status, grade, perineural invasion, and site in the oral cavity.
The evaluation of TILs as proposed by the International Immuno-Oncology Biomarker Working Group is a simple, inexpensive test. Morphological evaluation of TIL can provide valuable prognostic information in oral cavity squamous cell carcinoma cases and can be incorporated as a part of routine histopathological reporting.
口腔鳞状细胞癌是头颈部最常见的癌症之一。肿瘤浸润淋巴细胞是自然存在的单核细胞，浸润肿瘤微环境。本研究的目的是评估口腔鳞状细胞癌中的基质肿瘤浸润淋巴细胞（TIL）及其与临床病理参数（如年龄、性别、部位、肿瘤分期、淋巴结状态、分级、淋巴血管和神经周围侵犯）的相关性。
本研究共纳入 51 例接受切除术的口腔腔鳞状细胞癌患者。使用国际免疫肿瘤生物标志物工作组提出的评分标准，对苏木精和伊红染色的切片进行基质 TIL 评估。TIL 以百分比表示为连续评分，随后分为低 TIL（<20%）和高 TIL（≥20%）。使用 Fisher 精确/卡方检验评估 TIL 与临床病理参数之间的相关性。
在本研究评估的 51 例病例中，低 TIL 和高 TIL 分别占 25.5%和 74.5%。TIL 与肿瘤大小和淋巴血管侵犯有显著相关性。然而，在年龄、性别、淋巴结状态、分级、神经周围侵犯和口腔部位方面，TIL 与临床病理参数无显著相关性。
国际免疫肿瘤生物标志物工作组提出的 TIL 评估是一种简单、廉价的检测方法。TIL 的形态学评估可为口腔鳞状细胞癌病例提供有价值的预后信息，并可纳入常规组织病理学报告的一部分。
