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左心室功能受损患者冠状动脉旁路移植术的结局及术前心肌存活性的作用

Outcomes of Coronary Artery Bypass Grafting in Patients With Impaired Left Ventricular Function and the Role of Preoperative Myocardial Viability.

作者信息

Aasim Muhammad, Aziz Raheela, Mohsin Atta Ul, Khan Raheel, Zahid Ayesha, Awais Muhammad, Marquez Roa Leonardo A, Shaukat Nauman, Ikram Jibran

机构信息

Cardiac Surgery, Hayatabad Medical Complex Peshawar, Peshawar, PAK.

Cardiovascular Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK.

出版信息

Cureus. 2024 Dec 22;16(12):e76198. doi: 10.7759/cureus.76198. eCollection 2024 Dec.

Abstract

Background Coronary artery bypass grafting (CABG) improves outcomes in patients with ischemic left ventricular (LV) dysfunction, but accurate patient selection remains critical. Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging aids in assessing myocardial viability, a key predictor of surgical outcomes. This study aimed to evaluate the impact of myocardial viability on postoperative outcomes in patients undergoing CABG. Methods This was a single-center prospective analysis of clinical outcomes in 37 patients with impaired LV function (mean ejection fraction: 35.59%); myocardial viability was assessed using LGE-CMR prior to CABG. Patient demographics, perioperative details, and short-term outcomes, including in-hospital mortality and recovery metrics, were analyzed. Results Patients exhibited high myocardial viability (mean: 88.16%), with an average of 2.35 non-viable segments. In-hospital mortality was 5.4% (n=2), and the mean hospital stay was six days. Patients with greater viability demonstrated better recovery and fewer complications. Multivessel coronary artery disease was prevalent (94.6%, n=35), with tailored graft configurations addressing individual anatomical and disease complexities. Conclusion LGE-CMR is a valuable tool for predicting outcomes in ischemic LV dysfunction. Myocardial viability strongly correlates with improved surgical recovery, highlighting the importance of integrating LGE-CMR into preoperative decision-making. Further studies are required to explore the long-term impact of myocardial viability on treatment outcomes and quality of life.

摘要

背景 冠状动脉旁路移植术(CABG)可改善缺血性左心室(LV)功能障碍患者的预后,但准确的患者选择仍然至关重要。心脏磁共振(CMR)成像上的延迟钆增强(LGE)有助于评估心肌存活情况,这是手术预后的关键预测指标。本研究旨在评估心肌存活情况对接受CABG患者术后预后的影响。方法 这是一项对37例左心室功能受损患者(平均射血分数:35.59%)临床预后的单中心前瞻性分析;在CABG术前使用LGE-CMR评估心肌存活情况。分析患者的人口统计学特征、围手术期细节以及短期预后,包括住院死亡率和恢复指标。结果 患者表现出较高的心肌存活情况(平均:88.16%),平均有2.35个无存活心肌节段。住院死亡率为5.4%(n = 2),平均住院时间为6天。存活情况较好的患者恢复更好且并发症更少。多支冠状动脉疾病普遍存在(94.6%,n = 35),采用了针对个体解剖结构和疾病复杂性的定制移植配置。结论 LGE-CMR是预测缺血性左心室功能障碍预后的有价值工具。心肌存活情况与手术恢复改善密切相关,突出了将LGE-CMR纳入术前决策的重要性。需要进一步研究来探讨心肌存活情况对治疗结果和生活质量的长期影响。

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