对先前使用含第二代NS5A抑制剂、索磷布韦+格卡瑞韦/哌仑他韦和利巴韦林的方案治疗16 - 24周失败的慢性丙型肝炎3a型和肝硬化患者进行再治疗。
Retreatment of patients with chronic hepatitis C, subtype 3a, and cirrhosis, who previously failed a regimen containing second-generation NS5A inhibitors with sofosbuvir + glecaprevir/pibrentasvir and ribavirin for 16-24 weeks.
作者信息
Fedorchenko Sergii V, Klimenko Zhanna, Martynovich Tatiana, Solianyk Iryna, Suprunenko Tatiana
机构信息
Department of Viral Hepatitis and AIDS, The L.V. Gromashevskyi Institute of Epidemiology and Infectious Disease, Kyiv, Ukraine.
出版信息
J Virol. 2025 Feb 25;99(2):e0184324. doi: 10.1128/jvi.01843-24. Epub 2025 Jan 22.
Abstract
The outcomes of retreatment patients infected with hepatitis C virus genotype 3, cirrhosis, with velpatasvir may be affected by treatment failure with velpatasvir. The efficacy of SOF+GLE/PIB+RIB 16-24 weeks of treatment has been shown. The presence of NS5A resistance-associated substitution mutations, including Y93H, and the number and regimens of the past failed therapy do not influence the likelihood of achieving sustained virological response. When velpatasvir treatment fails, pibrentasvir should be used as the first choice for retreatment.
摘要
感染丙型肝炎病毒3型、肝硬化的患者接受维帕他韦再治疗的结果可能会受到维帕他韦治疗失败的影响。已显示索磷布韦+ glecaprevir / pibrentasvir治疗16 - 24周的疗效。包括Y93H在内的NS5A耐药相关替代突变的存在，以及过去失败治疗的次数和方案，均不影响实现持续病毒学应答的可能性。当维帕他韦治疗失败时，应将pibrentasvir作为再治疗的首选药物。
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