Kataria Saurabh, Inggas Made Agus Mahendra, Patel Utsav, Wijaya Jeremiah Hilkiah, Yabut Kevin, Ayub Muhammad Abubakar, Maniyar Pankti, Upadhyay Nihar, Davitashvili Beso, Patel Jayshil, Shah Siddhi, Turjman Tawfiq, Turjman Hisham, Shekoohi Sahar, Kaye Alan D
Department of Neurology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
Department of Neurosurgery, Universitas pelita harapan, Tangerang, Banten, Indonesia.
Curr Pain Headache Rep. 2025 Jan 22;29(1):29. doi: 10.1007/s11916-024-01331-6.
The use of stem cell therapy is a rapidly evolving and progressing frontier of science that has been used to treat illnesses such as malignancies, immunodeficiencies, and metabolic syndromes. This review aims to give an overview of the use of stem cell therapy in the treatment of pain caused by diabetic neuropathy, osteoarthritis, and other spinal cord pathologies.
Pain is defined as a generalized or localized feeling of distress related to a physical or emotional stimulus and can be caused by a multitude of pathologies. The field of pain management has explored many strategies such as gene therapies, neuromodulation, platelet-rich plasma, and numerous pharmacotherapies. The approach to the delivery of these strategies has varied, with the method of stem cell therapy delivery being the focus of this present investigation. In addition, we combined several different studies to analyze the effects of stem cell therapies and improvement in pain scores quantified by the visual analog scale (VAS). The overall results showed a mean difference of -2.58, suggesting that the stem cell treatment group had a lower VAS score at 6 months compared to the control group. The use of different types of stem cells, such as pluripotent and mesenchymal stem cells, play a critical role in the care of cases suffering from pain. Effective delivery methods are evolving and can transform treatment options in the future, for which large cohort studies are warranted.
干细胞疗法的应用是一个快速发展且不断进步的科学前沿领域，已被用于治疗诸如恶性肿瘤、免疫缺陷和代谢综合征等疾病。本综述旨在概述干细胞疗法在治疗糖尿病性神经病变、骨关节炎及其他脊髓疾病所致疼痛方面的应用。
疼痛被定义为与物理或情感刺激相关的一种全身性或局部性的痛苦感觉，可由多种病理状况引起。疼痛管理领域已探索了许多策略，如基因疗法、神经调节、富血小板血浆以及众多药物疗法。这些策略的实施方式各不相同，而干细胞疗法的给药方法是本研究的重点。此外，我们综合了多项不同研究，以分析干细胞疗法的效果以及通过视觉模拟量表（VAS）量化的疼痛评分改善情况。总体结果显示平均差异为 -2.58，这表明与对照组相比，干细胞治疗组在6个月时的VAS评分更低。使用不同类型的干细胞，如多能干细胞和间充质干细胞，在疼痛病例的治疗中起着关键作用。有效的给药方法正在不断发展，未来可能会改变治疗选择，为此有必要开展大型队列研究。
