Barbhuiya Pervej Alom, Ahmed Ameena, Dutta Partha Pratim, Sen Saikat, Pathak Manash Pratim
Faculty of Pharmaceutical Science, Assam down town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, Assam, India, PIN - 781026.
Centre for Research On Ethnomedicine, Faculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, Assam, India, PIN - 781026.
Curr Nutr Rep. 2025 Jan 22;14(1):20. doi: 10.1007/s13668-024-00598-w.
The term metabolic dysfunction-associated steatotic liver disease (MASLD) refers to a group of progressive steatotic liver conditions that include metabolic dysfunction-associated steatohepatitis (MASH), which has varying degrees of liver fibrosis and may advance to cirrhosis, and independent hepatic steatosis. MASLD has a complex underlying mechanism, with patients exhibiting diverse causes and phases of the disease. India has a pool prevalence of MASLD of 38.6% in adults. In 2023, the term NAFLD has been redefined and changed to MASLD. Currently, there are no drugs approved by the FDA for the treatment of MASLD. This study investigates the potential of bioactive phytoconstituents present in spices as a therapeutic approach for MASLD. Moreover, it offers comprehensive data on several pre-clinical studies of bioactive phytoconstituents derived from spices that primarily focus on treating obesity-associated MASLD.
Spices include a high amount of bioactive chemicals and several research have indicated their diverse pharmacological activities. Bioactive phytoconstituents from common Indian spices like cinnamic acid, eugenol, curcumin, allicin, 6-gingerols, capsaicin, piperine, eucalyptol, trigonelline, and linalool have been reported to exhibit anti-MASLD effects both in-vivo and in-vitro. Bioactive phytoconstituents from different culinary species of India have shown promising potential against MASLD in pre-clinical status. Further clinical studies on a large scale would be beneficial for paving the path to the development of a new drug which is the need of time.
代谢功能障碍相关脂肪性肝病（MASLD）这一术语指的是一组进行性脂肪性肝病，包括代谢功能障碍相关脂肪性肝炎（MASH），其具有不同程度的肝纤维化，可能进展为肝硬化，以及单纯性肝脂肪变性。MASLD具有复杂的潜在机制，患者表现出多种病因和疾病阶段。印度成年人中MASLD的总体患病率为38.6%。2023年，非酒精性脂肪性肝病（NAFLD）这一术语已被重新定义并改为MASLD。目前，美国食品药品监督管理局（FDA）尚未批准用于治疗MASLD的药物。本研究调查了香料中存在的生物活性植物成分作为MASLD治疗方法的潜力。此外，它还提供了关于几种源自香料的生物活性植物成分的临床前研究的全面数据，这些研究主要集中在治疗肥胖相关的MASLD。
香料含有大量生物活性化学物质，多项研究表明它们具有多种药理活性。据报道，来自印度常见香料如肉桂酸、丁香酚、姜黄素、大蒜素、6-姜酚、辣椒素、胡椒碱、桉叶油素、胡芦巴碱和芳樟醇的生物活性植物成分在体内和体外均表现出抗MASLD作用。来自印度不同烹饪品种的生物活性植物成分在临床前状态下对MASLD显示出有前景的潜力。进一步的大规模临床研究将有助于为开发一种新药铺平道路，这是当下的需求。
