Toma Faria Mehreen, Kalam Khondoker Tashya, Haque Md Aminul, Reza Sejuti, Akter Raushanara, Islam Mohammad Safiqul, Islam Md Rabiul, Nahar Zabun
Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.
School of Pharmacy, BRAC University, Dhaka, Bangladesh.
PLoS One. 2025 Jan 22;20(1):e0317665. doi: 10.1371/journal.pone.0317665. eCollection 2025.
Epidemiological research suggests that altered levels of cytokine are associated with pathophysiology and the development of major depressive disorder (MDD). Based on earlier study, IL-1β rs16944 and rs1143627 polymorphisms may increase the risk of depression. Here, we aimed to evaluate the correlation between these polymorphisms and MDD susceptibility among the population in Bangladesh.
Blood samples were collected from 100 MDD patients and 70 matched controls. Study participants were evaluated by DSM-5 criteria and PCR-RFLP method were applied for genotyping.
The IL1β rs1143627 and rs16944 polymorphisms were found to have a significant association with the risk of MDD. In case of rs1143627 CT heterozygous genotype (OR = 2.22, 95% CI = 1.08-4.55, p-value = 0.029) and combined CT+TT (OR = 2.35, 95% CI = 1.15-4.79, p-value = 0.019) genotype was strongly associated with the increased risk of MDD in comparison to CC common genotype. Moreover, the over-dominant model indicated a 2.15-fold higher risk for MDD development (OR = 2.15, 95% CI = 1.05-4.40, p-value = 0.036). On the other hand, the IL1β rs16944 polymorphisms revealed that the TC+CC combined genotype in the dominant model showed a 2.06-fold increased risk for MDD development compared to the TT common homozygote (OR = 2.06, 95% CI = 1.06-3.99, p-value = 0.032).
Studies suggests that IL1β rs16944 and rs1143627 polymorphisms are associated with an increased risk of MDD. These findings will provide us with valuable insights into the pathophysiology of MDD.
流行病学研究表明，细胞因子水平的改变与重度抑郁症（MDD）的病理生理学及发病相关。基于早期研究，白细胞介素-1β（IL-1β）基因rs16944和rs1143627多态性可能会增加患抑郁症的风险。在此，我们旨在评估孟加拉国人群中这些多态性与MDD易感性之间的相关性。
采集100例MDD患者和70例匹配对照的血样。研究参与者依据《精神疾病诊断与统计手册》第五版（DSM-5）标准进行评估，并采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法进行基因分型。
发现IL1β rs1143627和rs16944多态性与MDD风险显著相关。就rs1143627而言，CT杂合基因型（比值比[OR]=2.22，95%置信区间[CI]=1.08 - 4.55，p值=0.029）以及CT+TT组合基因型（OR = 2.35，95% CI = 1.15 - 4.79，p值=0.019）与CC常见基因型相比，与MDD风险增加密切相关。此外，超显性模型表明MDD发病风险高2.15倍（OR = 2.15，95% CI = 1.05 - 4.40，p值=0.036）。另一方面，IL1β rs16944多态性显示，显性模型中的TC+CC组合基因型与TT常见纯合子相比，MDD发病风险增加2.06倍（OR = 2.06，95% CI = 1.06 - 3.99，p值=0.032）。
研究表明，IL1β rs16944和rs1143627多态性与MDD风险增加相关。这些发现将为我们深入了解MDD的病理生理学提供有价值的见解。
